...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American journal of geriatric pharmacotherapy >Probable valproate sodium-associated hypotension.
【24h】

Probable valproate sodium-associated hypotension.

机译：丙戊酸钠可能引起的低血压。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Valproate sodium, a commonly used antiepileptic drug (AED), is effective for the treatment of status epilepticus and is often used as a second-line agent when other AEDs are contraindicated. Some studies have reported that infusion of valproate sodium is generally well tolerated, whereas other studies have reported various degrees of hypotension during infusion. The objective of this case report was to call attention to the potential risk of hypotension after intravenous infusion of valproate sodium. CASE SUMMARY: This was the case of a 75-year-old Hispanic man (height, 145 cm; weight, 68 kg) who developed hypotension after receiving an intravenous loading dose of valproate sodium. The patient received the loading dose 12 hours after administration of his last dose of phenytoin (300 mg daily), which had been discontinued secondary to a cutaneous drug reaction. The patient's medical history was significant for seizure disorder, a cerebrovascular accident, and controlled type 2 diabetes mellitus. He was taking glyburide 5 mg daily and aspirin 81 mg daily. At baseline, the patient's blood pressure (measured while seated, at rest, using an upper-extremity cuff) was 135/70 mm Hg. The intravenous loading dose of valproate sodium (20 mg/kg) was administered at a rate of 14 mg/min (total dose, 1280 mg over 90 min). Approximately 2.5 hours after completion of the loading dose, the patient's blood pressure decreased to 107/48 mm Hg. Because our standard operating procedure is to measure blood pressure every 4 hours after the baseline measurement, the patient's hypotension was not detected during the infusion. The next morning (22 hours after completion of the valproate sodium infusion), divalproex sodium 1000 mg orally once daily was initiated as maintenance therapy. The patient's blood pressure reached a nadir of 82/44 mm Hg. The hypotension was treated initially with intravenous fluid hydration with normal saline, but the blood pressure correction was transient using this approach. The patient remained hypotensive for 3 days. The hypotension was ultimately found to be self-limited, and the patient was asymptomatic throughout his hospital stay. The patient's Naranjo adverse drug reaction probability scale score was 6, indicating that the relationship between valproate sodium infusion and hypotension was probable. CONCLUSION: In this case report, infusion of valproate sodium at a rate of 14 mg/min was a probable cause of hypotension in a 75-year-old man.
机译：背景：丙戊酸钠是一种常用的抗癫痫药（AED），可有效治疗癫痫持续状态，在禁忌其他AED时常被用作二线药物。一些研究报道了丙戊酸钠的输注通常被很好地耐受，而其他研究报告了在输注过程中各种程度的低血压。该病例报告的目的是要引起人们注意静脉注射丙戊酸钠后低血压的潜在风险。病例总结：一名75岁的西班牙裔男子（身高145厘米;体重68公斤）在接受静脉注射丙戊酸钠剂量后出现低血压。患者在服用他的最后一剂苯妥英钠（每天300毫克）后12个小时接受了负荷剂量，该剂量已在皮肤药物反应后中止。该患者的病史对癫痫发作，脑血管意外和受控的2型糖尿病具有重要意义。他每天服用5格列本脲和每天81毫克阿司匹林。在基线时，患者的血压（坐着休息时使用上肢袖带测量）为135/70 mm Hg。丙戊酸钠的静脉内负荷剂量（20 mg / kg）以14 mg / min的速度给药（总剂量为1280 mg，历时90分钟）。负荷剂量完成后约2.5小时，患者的血压降至107/48毫米汞柱。因为我们的标准操作程序是在基线测量后每4小时测量一次血压，所以在输液期间未检测到患者的低血压。第二天早晨（完成丙戊酸钠输注后的22小时），开始每天口服一次1000 mg的divalproex钠作为维持疗法。患者的血压达到最低点82/44 mm Hg。最初用生理盐水静脉补液治疗低血压，但是使用这种方法可以暂时纠正血压。患者降压持续3天。最终发现低血压是自我限制的，患者在住院期间无症状。患者的Naranjo药物不良反应概率评分为6，表明丙戊酸钠输注与低血压之间的关系很可能。结论：在本病例报告中，丙戊酸钠以14 mg / min的速度输注是一名75岁男性低血压的可能原因。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号