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首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >Estrogen receptor α polymorphisms and the risk of cognitive decline: A 2-year follow-up study
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Estrogen receptor α polymorphisms and the risk of cognitive decline: A 2-year follow-up study

机译：雌激素受体α多态性与认知能力下降的风险：一项为期两年的随访研究

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Objective: The neuroprotective role of estrogen is supported by biochemical studies, but the results from clinical trials of estrogen replacement therapy on cognitive decline are controversial. One possible missing link might be the interindividual difference in estrogen receptor expression. In this study, the association of estrogen receptor α (ESR1) polymorphisms and cognitive decline was investigated. Methods: Chinese older adults (n =284) were recruited, and the cognitive profile was follow-up over 2-year period. Twenty ESR1 polymorphisms were investigated and correlated with the cognitive decline for the subjects. Results: Significant association was found between ESR1 polymorphisms (rs9340799 [ESR1+351], rs1801132 [ESR1+975], rs6557171, rs9397456, and rs1884049) and subjects with no dementia (Clinical Dementia Rating, CDR 0) and very mild dementia (CDR 0.5). Several ESR1 polymorphisms were associated with cognitive decline as assessed by Chinese versions of Mini-Mental State Examination and Alzheimer Disease Association Scales-Cognitive Subscale. Different sets of ESR1 polymorphisms were associated with cognitive decline from CDR 0 to 0.5 and CDR 0.5 to 1. ESR1 polymorphisms (rs3853248, rs22334693 [ESR1+397], rs9340799 [ESR1+351], rs9397456, rs1801132 [ESR1+975], rs2179922, rs932477, and rs9341016) were associated with the deterioration of episodic memory among subjects with baseline CDR 0, indicating these polymorphisms might be markers for episodic memory decline at an earlier stage. Conclusion: This study showed association between ESR polymorphisms and cognitive decline or specific areas in cognitive profile. These findings might be useful in identifying individuals at risk for early intervention, and more research is required to elucidate the underlying mechanisms.
机译：目的：生化研究支持雌激素的神经保护作用，但雌激素替代疗法对认知功能下降的临床试验结果存在争议。一个可能的缺失环节可能是雌激素受体表达的个体差异。在这项研究中，雌激素受体α（ESR1）多态性与认知能力下降的关联进行了调查。方法：招募中国老年人（n = 284），并对其认知情况进行为期两年的随访。研究了20个ESR1多态性，并将其与受试者的认知能力下降相关联。结果：发现ESR1多态性（rs9340799 [ESR1 + 351]，rs1801132 [ESR1 + 975]，rs6557171，rs9397456和rs1884049）与无痴呆症（临床痴呆评分，CDR 0）和轻度痴呆（CDR）之间存在显着关联。 0.5）。根据中文版的《迷你精神状态检查》和《阿尔茨海默病协会量表-认知子量表》评估，一些ESR1多态性与认知能力下降有关。 ESR1多态性的不同集合与认知下降从CDR 0到0.5和CDR 0.5到1相关（rs932477和rs9341016）与基线CDR 0的受试者中情节性记忆的恶化相关，表明这些多态性可能是早期情节性记忆下降的标志。结论：这项研究表明ESR多态性与认知能力下降或认知特征中的特定区域之间存在关联。这些发现可能有助于识别有早期干预风险的个体，需要更多的研究来阐明其潜在机制。

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