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首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >Memantine for Lewy Body Disorders: Systematic Review and Meta-Analysis
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Memantine for Lewy Body Disorders: Systematic Review and Meta-Analysis

机译：美金刚对路易体疾病的系统评价和荟萃分析

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Objective: To clarify whether memantine is more efficacious in several outcomes and safer than placebo in patients with Lewy body disorders, we performed a meta-analysis of memantine in patients with Lewy body disorders. Methods: The meta-analysis included randomized controlled trials of memantine for Lewy body disorders in all patients with Lewy body disorders. Motor function, activities of daily living, Neuropsychiatric Inventory, Mini-Mental State Exam, discontinuation rate, and individual side effects were evaluated. Results: No significant effects of memantine on motor function scores, Mini-Mental State Exam scores, Neuropsychiatric Inventory scores, and activity of daily living scores were found. However, memantine was superior to placebo in Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change scores (standardized mean difference: -0.26; 95% confidence interval: -0.51 to -0.02; z = 2.08; p = 0.04; two studies; N = 258). Dropout due to all causes, inefficacy, or adverse events were similar in both groups. Moreover, no significant differences in serious adverse events, somnolence/tiredness, stroke, dizziness/vertigo, and confusion were found between the groups. Conclusion: Our results suggest that memantine did not have a benefit for the treatment of Lewy body disorders in cognition and motor function. However, memantine may be superior to placebo for the overall impression of the disorders. Further, memantine is well tolerated.
机译：目的：为阐明路易氏体病患者美金刚在某些结局方面是否比安慰剂更有效且更安全，我们对路易氏体病患者进行了美金刚的荟萃分析。方法：荟萃分析包括美金刚对所有路易体病患者的路易体病的随机对照试验。评估了运动功能，日常生活活动，神经精神病学量表，小精神状态检查，停药率和个体副作用。结果：美金刚胺对运动功能评分，小精神状态检查评分，神经精神病学量表评分和日常生活活动评分均无显着影响。但是，在阿尔茨海默氏病合作研究-临床整体变化印象评分中，美金刚优于安慰剂（标准化平均差异：-0.26; 95％置信区间：-0.51至-0.02; z = 2.08; p = 0.04;两项研究; N = 258）。两组的所有原因，无效或不良事件导致的辍学率相似。此外，两组之间在严重不良事件，嗜睡/疲倦，中风，头晕/眩晕和意识模糊方面无显着差异。结论：我们的结果表明，美金刚对路易体疾病的认知和运动功能没有益处。然而，美金刚对于疾病的总体印象可能优于安慰剂。此外，美金刚耐受性良好。

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