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首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >Oxidative Stress in Older Patients with Bipolar Disorder
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Oxidative Stress in Older Patients with Bipolar Disorder

机译：老年双相情感障碍患者的氧化应激

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Objective: Increases in oxidative stress have been consistently reported in younger patients with bipolar disorder (BD) in postmortem brain and blood samples studies. Changes in oxidative stress are also associated with the natural aging process. Thus, the investigation of oxidative stress across the life span of patients with BD is crucial. Methods: We compared the levels of oxidative damage to proteins and lipids in plasma from 110 euthymic older patients with BD I or II (mean +/- SD age: 63.9 +/- 9.7 years) and 75 older healthy individuals (66.0 +/- 9.6 years). To assess protein oxidation, we measured the plasma levels of protein carbonyl (PC) and 3-nitrotyrosine (3-NT) using the ELISA technique. To assess lipid peroxidation, we measured plasma levels of lipid hydroperoxide (LPH) and 4-hydroxynonenal (4-HNE) using spectrophotometric assays. Results: LPH levels were higher in patients than in the comparison healthy individuals, whereas there were no significant differences for PC, 3-NT, and 4-HNE between the two groups. Conclusions: The increased levels of an early component of the peroxidation chain (LPH) in euthymic older patients with BD support the hypothesis of a persistent effect of reactive species of oxygen in patients with BD into late life.
机译：目的：在死后大脑和血液样本研究中，年轻双相情感障碍（BD）的年轻患者一直一致报道氧化应激的增加。氧化应激的变化也与自然老化过程有关。因此，研究BD患者整个生命过程中的氧化应激至关重要。方法：我们比较了110例BD I或II正常患者（平均+/- SD年龄：63.9 +/- 9.7岁）和75例健康的老年人（66.0 +/-）对血浆蛋白质和脂质的氧化损伤水平。 9.6年）。为了评估蛋白质氧化，我们使用ELISA技术测量了血浆蛋白羰基（PC）和3-硝基酪氨酸（3-NT）的水平。为了评估脂质过氧化作用，我们使用分光光度法测定了血浆脂质过氧化氢（LPH）和4-羟基壬烯醛（4-HNE）的水平。结果：患者的LPH水平高于健康人，而两组之间PC，3-NT和4-HNE的差异无统计学意义。结论：正常人BD患者中过氧化链（LPH）早期成分水平的增加支持了BD患者中的活性氧持续存在至晚年的假设。

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