• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >Self-Rated and Caregiver-Rated Quality of Life in Alzheimer Disease with a Focus on Evolving Patient Ability to Respond to Questionnaires: 5-Year Prospective ALSOVA Cohort Study
【24h】

Self-Rated and Caregiver-Rated Quality of Life in Alzheimer Disease with a Focus on Evolving Patient Ability to Respond to Questionnaires: 5-Year Prospective ALSOVA Cohort Study

机译：阿尔茨海默病患者的自评和看护者评价的生活质量，重点是不断发展的患者对问卷的反应能力：5年前瞻性ALSOVA队列研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: To examine and compare self-rated and caregiver-rated measures of quality of life (QoL) in relation to disease progression in patients with very mild or mild Alzheimer disease (AD) and at what disease stage patient's ability to respond to QoL questionnaires with or without assistance begins to diminish. Methods: 236 patients with very mild or mild AD and their family caregivers from three Finnish hospital districts participated in this prospective, longitudinal study with 5 years of follow-up. Three patient-reported instruments were used to assess QoL (the generic 15D, the Quality of Life in Alzheimer Disease [QoL-AD] questionnaire, and a visual analogue scale) as well as one caregiver-rated assessment of patient QoL (QoL-AD). AD severity was evaluated with the Clinical Dementia Rating Scale - Sum of Boxes (CDR-SOB). Results: All self-and caregiver-rated QoL estimates correlated with AD severity. The self-and caregiver-rated QoL scores began to diverge even with very mild cognitive impairment after CDR-SOB reached 4, the value that corresponds with a Mini-Mental State Examination (MMSE) score of 25-30. Patients also began to need assistance in responding to questionnaires at very early stages of AD (CDR-SOB score: 4-6). Furthermore, their ability to respond to QoL questionnaires with or without assistance declined after CDR-SOB reached 11 points, a value that correlates with an early moderate stage of AD and MMSE score of 11-20. Conclusions: AD patients' self-rated QoL ratings are much more insensitive to disease progression than caregiver ratings.
机译：目的：检查和比较与轻度或轻度阿尔茨海默病（AD）患者的疾病进展有关的生活质量（QoL）自我评估和照护者评估以及在什么疾病阶段患者对QoL问卷的反应能力在有或没有援助的情况下开始减少。方法：来自三个芬兰医院地区的236名极轻或轻度AD患者及其家属均参加了这项为期5年的随访的前瞻性纵向研究。使用了三种患者报告的仪器来评估QoL（通用15D，阿尔茨海默氏病的生活质量[QoL-AD]调查表和视觉模拟量表），以及一项对患者QoL进行护理者评估的评估（QoL-AD ）。用临床痴呆症评定量表-盒总和（CDR-SOB）评估AD严重程度。结果：所有自我和照料者评估的QoL估计都与AD严重程度相关。在CDR-SOB达到4之后，即使有非常轻微的认知障碍，自我和护理者评分的QoL评分也开始出现差异，该值与25-30的最低精神状态检查（MMSE）评分相对应。在AD的早期阶段（CDR-SOB评分：4-6），患者也开始需要帮助来答复问卷。此外，在CDR-SOB达到11分之后，无论有无帮助，他们对QoL问卷的回答能力均下降，该值与AD和MMSE早期中等阶段得分11-20相关。结论：AD患者的自我评估QoL评估比照护者评估对疾病进展更为不敏感。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号