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首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >Examining the Pathways Between Self-Awareness and Well-Being in Mild to Moderate Alzheimer Disease
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Examining the Pathways Between Self-Awareness and Well-Being in Mild to Moderate Alzheimer Disease

机译：研究轻度至中度阿尔茨海默病患者自我意识与幸福感之间的关系

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Objective: To investigate the relationship between awareness of memory loss and psychological well-being in a nonclinically depressed sample of participants with mild to moderate Alzheimer disease (AD). Methods: Study participants (N = 104) enrolled through Columbia University Medical Center and the University of Pennsylvania completed clinical and cognitive assessments. Participants were rated with regard to their degree of awareness of memory deficits and completed questionnaires relating to their psychological well-being, including mood and quality of life (QOL). Mediating models were used to establish the relationship between awareness, depression, and QOL and to examine potential mediators of awareness and depression, including psychological distress, objective memory deficits, and negative self-ratings. Results: There was a direct association between awareness of memory deficits and depressed mood but not awareness and QOL. However, there was an indirect association between awareness and QOL through depression. Neither psychological distress, memory deficits, nor negative self-ratings mediated the relationship between awareness and depression. Conclusion: Awareness is associated with depressed mood in nonclinically depressed participants with mild to moderate AD. However, depressed mood does not appear to reflect the direct psychological reaction to awareness of memory loss. Moreover, awareness has only an indirect association with QOL via depressed mood. These results suggest that preserved awareness does not have a direct negative impact on overall psychological well-being in AD.
机译：目的：探讨轻度至中度阿尔茨海默病（AD）参与者的非临床抑郁样本中记忆力丧失意识与心理健康之间的关系。方法：参加哥伦比亚大学医学中心和宾夕法尼亚大学的研究参与者（N = 104）完成了临床和认知评估。评估参与者对记忆力不足的认识程度，并完成与他们的心理健康（包括情绪和生活质量）有关的问卷调查。中介模型用于建立意识，抑郁和生活质量之间的关系，并检查意识和抑郁的潜在中介者，包括心理困扰，客观记忆缺陷和负面的自我评价。结果：记忆力减退的意识与情绪低落之间存在直接的关联，但意识与生活质量却没有直接的联系。然而，通过抑郁症，意识和生活质量之间存在间接联系。心理困扰，记忆力减退或负面的自我评价均未介导意识与抑郁之间的关系。结论：意识与轻度至中度AD的非临床抑郁参与者的情绪低落有关。但是，情绪低落似乎并未反映出对记忆丧失意识的直接心理反应。而且，意识只是通过情绪低落与生活质量间接相关。这些结果表明，保持意识不会对AD的整体心理健康产生直接的负面影响。

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