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首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >Mortality in Mild Cognitive Impairment Diagnosed with DSM-5 Criteria and with Petersen's Criteria: A 17-Year Follow-Up in a Community Study
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Mortality in Mild Cognitive Impairment Diagnosed with DSM-5 Criteria and with Petersen's Criteria: A 17-Year Follow-Up in a Community Study

机译：DSM-5标准和彼得森标准诊断的轻度认知障碍死亡率：一项社区研究的17年随访

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Objective: To explore the possibility that the mortality risk of mild cognitive impairment (MCI) as diagnosed using Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria (DSM-5-MCI) will be higher than using Petersen's criteria (P-MCI) and to report the population-attributable fraction (PAF) of mortality due to MCI. Methods: A representative community sample of 4,803 individuals aged 55 or more years was interviewed and then followed for 17 years. Standardized instruments were used in the assessment, including the Geriatric Mental State-AGECAT, and research psychiatrists diagnosed P-MCI and DSM-5-MCI cases following operationalized criteria. Mortality information was obtained from the official population registry. Kaplan-Meier age-adjusted survival curves were built for the MCI diagnostic groups, and Cox proportional hazards regression models were used to calculate the hazard ratio of death in participants with MCI relative to those without. We also estimated the PAF of mortality due to specific MCI diagnostic groups. Results: Compared with noncases, the mortality rate ratio was approximately double in DSM-5-MCI individuals (2.3) than in P-MCI individuals (1.2). In themultivariate statistical analysis, a significant association between each diagnostic category and mortality was observed but was only maintained in the final model in DSM-5-MCI cases (hazard ratio: 1.24). The PAF of mortality due to MCI was approximately 1% in both MCI categories. Conclusion: The mortality risk in comparison with noncases was higher in DSM-5MCI than in P-MCI. The PAF of mortality in DSM-5-MCI individuals was similar to 1% over a 17-year period.
机译：目的：探讨根据《精神疾病诊断和统计手册》第五版（DSM-5）标准（DSM-5-MCI）诊断的轻度认知障碍（MCI）的死亡风险高于彼得森标准的可能性（P-MCI），并报告由MCI导致的死亡率的人口归因分数（PAF）。方法：对一个有代表性的社区样本进行了访谈，调查对象是4803名55岁或以上的人，然后随访17年。评估中使用了标准化的工具，包括老年精神状态-AGECAT，研究精神病医生按照可操作的标准诊断为P-MCI和DSM-5-MCI病例。死亡率信息是从官方人口登记处获得的。为MCI诊断组建立了Kaplan-Meier年龄校正的生存曲线，并使用Cox比例风险回归模型来计算MCI参与者相对于无MCI参与者的死亡危险比。我们还估计了由于特定的MCI诊断组而导致的PAF死亡率。结果：与非病例相比，DSM-5-MCI个人的死亡率（2.3）大约是P-MCI个人的死亡率（1.2）的两倍。在多变量统计分析中，观察到每个诊断类别与死亡率之间的显着相关性，但仅在DSM-5-MCI病例的最终模型中得以保持（危险比：1.24）。在两种MCI类型中，因MCI导致的PAF死亡率约为1％。结论：与非病例相比，DSM-5MCI的死亡风险高于P-MCI。在17年中，DSM-5-MCI个人的PAF死亡率接近1％。

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