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首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >A three-country randomized controlled trial of a psychosocial intervention for caregivers combined with pharmacological treatment for patients with Alzheimer disease: effects on caregiver depression.
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A three-country randomized controlled trial of a psychosocial intervention for caregivers combined with pharmacological treatment for patients with Alzheimer disease: effects on caregiver depression.

机译：一项针对照护者的心理社会干预与药物治疗相结合的三国随机对照试验，用于阿尔茨海默病患者：对照护者抑郁的影响。

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OBJECTIVE: To evaluate the effectiveness of a combination of cholinesterase inhibitor therapy for patients with Alzheimer disease (AD) and psychosocial intervention, for their spouse caregivers compared with drug treatment alone in three countries simultaneously. DESIGN: Randomized controlled trial. Structured questionnaires were administered at baseline and at regular follow-up intervals for 24 months by independent raters blind to group assignment. SETTING: Outpatient research clinics in New York City, U.S., Manchester, U.K. and Sydney, Australia. PARTICIPANTS: Volunteer sample of 158 spouse caregivers of community dwelling patients with AD. INTERVENTIONS: Five sessions of individual and family counseling within 3 months of enrollment and continuous availability of ad hoc telephone counseling were provided for half the caregivers. Donepezil was prescribed for all patients. MAIN OUTCOME MEASURE: Depressive symptoms of spouse caregivers measured at intake and follow-up assessments for 24 months using Beck Depression Inventory (revised). RESULTS: Depression scores of caregivers who received counseling decreased over time, whereas the depression scores for caregivers who did not receive counseling increased. The benefit of the psychosocial intervention was significant after controlling for site, gender and country was not accounted for by antidepressant use and increased over 2 years even though the individual and family counseling sessions occurred in the first 3 months. CONCLUSION: Effective counseling and support interventions can reduce symptoms of depression in caregivers when patients are taking donepezil. Harmonized multinational psychosocial interventions are feasible. Combined drug and supportive care approaches to the management of people with AD should be a priority.
机译：目的：评估胆碱酯酶抑制剂联合治疗对阿尔茨海默病（AD）患者和心理社会干预患者配偶的护理效果，同时比较在三个国家中单独进行药物治疗的效果。设计：随机对照试验。由对小组分配不知情的独立评估者在基线和定期随访的间隔24个月内进行结构化问卷调查。地点：美国纽约，英国曼彻斯特和澳大利亚悉尼的门诊研究诊所。参与者：158例患有AD的社区居民患者的配偶照顾者的志愿者样本。干预措施：一半的看护者在入学后的三个月内提供了五次个人和家庭咨询服务，并持续提供了专门的电话咨询服务。多奈哌齐适用于所有患者。主要观察指标：使用贝克抑郁量表（修订版）在24个月的摄入量和随访评估中测得的配偶照顾者的抑郁症状。结果：随着时间的流逝，接受咨询的照料者的抑郁评分降低，而未接受咨询的照料者的抑郁评分升高。在控制部位，性别和国家后，抗抑郁药使用并未对社会心理干预的收益产生重大影响，尽管个人和家庭咨询会议是在前三个月进行的，但在过去的两年中，心理社会干预的收益有所增加。结论：有效的咨询和支持干预措施可以减轻患者服用多奈哌齐时护理人员的抑郁症状。统一的多国社会心理干预措施是可行的。将药物和支持性护理相结合的方法用于AD患者的管理应成为优先事项。

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