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首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >Psychological well-being and regional brain amyloid and tau in mild cognitive impairment
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Psychological well-being and regional brain amyloid and tau in mild cognitive impairment

机译：轻度认知障碍的心理健康和局部脑淀粉样蛋白和tau蛋白

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Objectives: To determine whether psychological well-being in people with mild cognitive impairment (MCI), a risk state for Alzheimer disease (AD), is associated with in vivo measures of brain pathology. Methods: Cross-sectional clinical assessments and positron emission tomography (PET) scans after intravenous injections of 2-(1-{6-[(2-[F18]fluoroethyl)(methyl)amino]-2- naphthyl}ethylidene) malononitrile (FDDNP), a molecule that binds to plaques and tangles, were performed on middle-aged and older adults at a university research institute. Volunteers were aged 40e85 years with MCI (N = 35) or normal cognition (N = 29) without depression or anxiety. Statistical analyses included general linear models, using regional FDDNP-PET binding values as dependent variables and the Vigor-Activity subscale of the Profile of Mood States (POMS) as the independent variable, covarying for age. The POMS is a self-rated inventory of 65 adjectives that describe positive and negative feelings. Results: Scores on the POMS Vigor-Activity subscale were inversely associated with degree of FDDNP binding in the posterior cingulate cortex (r = 0.35, p = 0.04) in the MCI group but not in the control group. Conclusion: Psychological well-being, as indicated by self-reports of greater vigor and activity, is associated with lower FDDNP-PET binding in the posterior cingulate cortex, a region involved in emotional regulation, in individuals with MCI but not in those with normal cognition. These findings are consistent with previous work indicating that deposition of brain amyloid plaques and tau tangles may result in noncognitive and cognitive symptoms in persons at risk for AD.
机译：目的：确定患有轻度认知障碍（MCI），阿尔茨海默病（AD）的危险状态的人的心理健康状况是否与体内脑病理学指标相关。方法：静脉内注射2-（1- {6-[（2- [F18]氟乙基）（甲基）氨基] -2-萘基}亚乙基丙二腈（）后，进行横断面临床评估和正电子发射断层扫描（PET）扫描FDDNP）是一种结合斑块和缠结的分子，是在大学研究机构对中老年人进行的。志愿者年龄在40-85岁之间，患有MCI（N = 35）或正常认知（N = 29），而没有抑郁或焦虑。统计分析包括一般线性模型，使用区域FDDNP-PET结合值作为因变量，使用情绪状态概貌的活力活动子量表（POMS）作为自变量，随年龄变化。 POMS是对65个形容词的自我评价，描述了正面和负面的感觉。结果：在MCI组中，扣带后部扣带皮层中FDDNP的结合程度与POMS活力-活动子量表的得分呈负相关（r = 0.35，p = 0.04），而在对照组中则没有。结论：自我报告的活力和活动能力增强表明，心理健康与MCI患者但在扣带回后皮层（参与情绪调节的区域）中FDDNP-PET结合降低有关认识。这些发现与以前的研究结果一致，表明脑淀粉样蛋白斑块和tau缠结的沉积可能导致有AD风险的人出现非认知和认知症状。

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