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首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >Better memory functioning associated with higher total and low-density lipoprotein cholesterol levels in very elderly subjects without the apolipoprotein e4 allele.
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Better memory functioning associated with higher total and low-density lipoprotein cholesterol levels in very elderly subjects without the apolipoprotein e4 allele.

机译：在没有载脂蛋白e4等位基因的非常老的受试者中，更好的记忆功能与较高的总和低密度脂蛋白胆固醇水平相关。

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摘要

OBJECTIVE: To examine the association of cholesterol with cognitive functioning in oldest old community dwelling individuals with and without the apolipoprotein e4 (APOE4) allele. METHOD: One hundred eighty-five nondemented, community dwelling individuals (>or=85) were assessed with a broad neuropsychological battery. Bloods were drawn to assess total, low-density lipoprotein (LDL), and high-density lipoprotein cholesterol, as well as for APOE genotyping. RESULTS: In contrast to our expectations, high total cholesterol and high LDL cholesterol were associated with higher memory scores for noncarriers of the APOE4 allele. No significant associations between cognitive performance and lipid profile were found for carriers of the APOE4 allele. CONCLUSIONS: In oldest old nondemented noncarriers of the APOE4 allele, high cholesterol is associated with better memory function. Further examination of the role of APOE genotype on the association between cholesterol and cognitive performance, especially in the oldest old is warranted.
机译：目的：研究胆固醇在有和没有载脂蛋白e4（APOE4）等位基因的最老的老年社区居民中的认知功能。方法：用广泛的神经心理学方法评估了一百八十五名无痴呆的社区居民（≥85）。抽血以评估总的，低密度脂蛋白（LDL）和高密度脂蛋白胆固醇，以及进行APOE基因分型。结果：与我们的预期相反，高总胆固醇和高LDL胆固醇与APOE4等位基因非携带者的较高记忆评分相关。没有发现APOE4等位基因携带者的认知能力与血脂水平之间存在显着关联。结论：在APOE4等位基因中最老的，非痴呆的非携带者中，高胆固醇与更好的记忆功能有关。有必要进一步检查APOE基因型在胆固醇和认知能力之间的关系上的作用，尤其是对于最老的老年人。

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