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首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >Validation of the Lille's Apathy Rating Scale in Very Mild to Moderate Dementia
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Validation of the Lille's Apathy Rating Scale in Very Mild to Moderate Dementia

机译：里尔的轻度至中度痴呆评分标准的验证

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Objective: Apathy is one of the most common and disabling syndromes of dementia and presents at all stages of the disease. Comprehensive and structured methods to assess apathy in dementia are still needed. Lille's Apathy Rating Scale (LARS) has shown good psychometric properties for apathy evaluation in Parkinson disease but has not been validated in dementia. The aim of this study was to validate the LARS in a cohort of patients with very mild to moderate dementia. Methods: 101 patients with cognitive impairment (Clinical Dementia Rating <= 2) and 50 healthy subjects were recruited. Patient diagnoses included 43 individuals with Alzheimer disease, 41 frontotemporal dementia, and 17 primary progressive aphasia. In addition to LARS, the following assessments were administered: Clinical Dementia Rating, Interview for Deterioration in Daily Living Activities in Dementia, Functional Activities Questionnaire, Frontal Behavioral Inventory, Neuropsychiatric Inventory (NPI), and Hamilton Depression Rating Scale. Results: Internal consistency for LARS (Cronbach's alpha) was 0.940. Test-retest intraclass correlation coefficient (ICC) was 0.940 and inter-rater ICC was 0.987. The correlation among LARS and NPI apathy scores (concurrent validity) was 0.834. Receiver operating characteristic analysis estimated an area under the curve of 0.987. The optimal cutoff point was -10. Although total LARS score was influenced by the presence of depression, this disorder was independent with respect to apathy. Conclusion: LARS is reliable and valid for detecting and quantifying apathy in patients with dementia, even in very early stages of the disease.
机译：目的：冷漠是痴呆症最常见且致残的综合征之一，并在疾病的所有阶段均表现出来。仍然需要用于评估痴呆症的冷漠的综合和结构化方法。里尔的冷漠评定量表（LARS）在帕金森病的冷漠评估中显示出良好的心理计量学性质，但尚未在痴呆症中得到验证。本研究的目的是在一群轻度至中度痴呆患者中验证LARS。方法：招募101名认知障碍患者（临床痴呆评分<= 2）和50名健康受试者。患者诊断包括43名患有阿尔茨海默氏病，41名额颞叶痴呆和17名原发性进行性失语症患者。除LARS之外，还进行了以下评估：临床痴呆评分，对痴呆患者日常生活活动恶化的访谈，功能活动问卷，额叶行为量表，神经精神量表（NPI）和汉密尔顿抑郁量表。结果：LARS的内部一致性（Cronbach's alpha）为0.940。重测组内相关系数（ICC）为0.940，评估者间ICC为0.987。 LARS和NPI冷漠评分之间的相关性（并行有效期）为0.834。接收器工作特性分析估计曲线下的面积为0.987。最佳截止点是-10。尽管总的LARS评分受抑郁症的影响，但该疾病在冷漠方面是独立的。结论：即使在疾病的早期，LARS仍能可靠且有效地检测和量化痴呆患者的冷漠。

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