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Treatment-resistant depression in adolescents: recognition and management.

机译:青少年难治性抑郁症:认识和管理。

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摘要

Approximately 20% of adolescents experience at least one depressive episode by the time they enter their adult years. For most adolescents, depression, although serious, either remits spontaneously or responds to treatment. For a smaller but significant proportion of adolescents, however, depression can be long-lasting and relatively unresponsive to initial treatment. In this article the authors provide an operational definition of treatment-resistant depression, identify factors associated with treatment nonresponse, describe an approach to the management of treatment-resistant depression, and advance suggestions for promising avenues of research.
机译:大约20%的青少年在进入成年年龄时会经历至少一次抑郁发作。对于大多数青少年来说,抑郁症虽然很严重,但可以自发缓解或对治疗产生反应。然而,对于较小但相当大比例的青少年,抑郁症可能会持续很长时间,并且对初始治疗的反应相对较差。在本文中,作者提供了抗抑郁药的操作性定义,确定与治疗无反应相关的因素,描述了抗抑郁药的治疗方法,并为有前途的研究途径提出了建议。

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