Cyclosporin combined with methotrexate in two patients with recalcitrant subacute cutaneous lupus erythematosus.

Klein A; Vogt T; Wenzel SM; Fleck M; Landthaler M

首页> 外文期刊>The Australasian journal of dermatology >Cyclosporin combined with methotrexate in two patients with recalcitrant subacute cutaneous lupus erythematosus.

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Cyclosporin combined with methotrexate in two patients with recalcitrant subacute cutaneous lupus erythematosus.

机译：环孢菌素联合氨甲蝶呤治疗顽固性亚急性皮肤性红斑狼疮2例。

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The treatment of subacute cutaneous lupus erythematosus is a therapeutic challenge. Frequently, patients are resistant to or intolerant towards single selected immunosuppressants. In combination, lower doses of methotrexate and cyclosporin A might be used to minimize toxicity. This is the first report of a successful combination of these drugs in two patients suffering from subacute cutaneous lupus erythematosus refractory to standard treatment.

机译：亚急性皮肤性红斑狼疮的治疗是治疗上的挑战。通常，患者对单一选择的免疫抑制剂有抗性或不耐受性。结合使用较低剂量的甲氨蝶呤和环孢菌素A可使毒性降至最低。这是成功将这两种药物联合用于两名标准治疗难治的亚急性皮肤性红斑狼疮患者的首次报道。

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《The Australasian journal of dermatology》 |2011年第1期|共5页
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Klein A; Vogt T; Wenzel SM; Fleck M; Landthaler M;
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正文语种 eng
中图分类皮肤病学与性病学;
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1. Cyclosporin combined with methotrexate in two patients with recalcitrant subacute cutaneous lupus erythematosus. [J] . Klein A, Vogt T, Wenzel SM, The Australasian journal of dermatology . 2011,第1期

机译：环孢菌素联合氨甲蝶呤治疗顽固性亚急性皮肤性红斑狼疮2例。
2. Demethylation of promoter regulatory elements contributes to CD70 overexpression in CD4+ T cells from patients with subacute cutaneous lupus erythematosus. [J] . Luo Y, Zhao M, Lu Q Clinical and experimental dermatology . 2010,第4期

机译：启动子调节元件的去甲基化导致亚急性皮肤性红斑狼疮患者的CD4 + T细胞中CD70过表达。
3. DNA demethylation of the perforin promoter in CD4(+) T cells from patients with subacute cutaneous lupus erythematosus. [J] . Luo Y, Zhang X, Zhao M, Journal of dermatological science . 2009,第1期

机译：亚急性皮肤性红斑狼疮患者CD4（+）T细胞中穿孔素启动子的DNA脱甲基化。
4. Clinical effectiveness of combined virtual reality and robot assisted fine hand motion rehabilitation in subacute stroke patients [C] . Xianwei Huang, Fazel Naghdy, Golshah Naghdy, 2017 International Conference on Rehabilitation Robotics . 2017

机译：亚急性中风患者结合虚拟现实和机器人辅助精细手部运动康复的临床效果
5. The Association of Cancer Development in Patients with Systemic Lupus Erythematosus. [D] . Coley, Rose Michelle. 2016

机译：系统性红斑狼疮患者的癌症发展协会。
6. Human histocompatibility antigen associations in subacute cutaneous lupus erythematosus. [O] . R D Sontheimer, P Stastny, J N Gilliam 1981

机译：亚急性皮肤红斑狼疮中的人类组织相容性抗原关联。
7. Association of a Promoter Polymorphism of Tumor Necrosis Factor-α with Subacute Cutaneous Lupus Erythematosus and Distinct Photoregulation of Transcription1,21Werth VP, Sullivan K: Strong association of a promoter polymorphism of tumor necrosis factors α with a photosensitive form of cutaneous lupus erythematosus. Arthr Rheum 42:S105 1999 (abstr.)2Werth VP, Zhang W, Sullivan K: Role of a promoter polymorphism of tumor necrosis factor-α (TNF-α) in a photosensitive form of lupus erythematosus (LE): clinical association and distinct photoregulation of transcription. J Invest Dermatol 114:770 2000 (abstr.) [O] . Werth Victoria P., Zhang Wei, Dortzbach Kathy, 2000

机译：肿瘤坏死因子-α启动子多态性与亚急性皮肤性红斑狼疮和转录的明显光调节相关1,21Werth VP，Sullivan K：肿瘤坏死因子α的启动子多态性与光敏性皮肤性红斑狼疮有很强的联系。 Arthr Rheum 42：S105 1999（摘要）2沃特VP，张W，沙利文K：肿瘤坏死因子-α（TNF-α）启动子多态性在红斑狼疮（LE）的光敏形式中的作用：临床关联和独特之处转录的光调节。 J投资皮肤病杂志114：770 2000（摘要）

Cyclosporin combined with methotrexate in two patients with recalcitrant subacute cutaneous lupus erythematosus.

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