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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Prediction of remission and recovery in young people presenting with first-episode psychosis in Hong Kong: A 3-year follow-up study
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Prediction of remission and recovery in young people presenting with first-episode psychosis in Hong Kong: A 3-year follow-up study

机译：对香港首发精神病的年轻人的缓解和恢复的预测：一项为期三年的随访研究

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Objective: The aim of the current study was to investigate the rates and predictors of symptomatic remission and recovery in patients presenting with first-episode psychosis 3 years after treatment initiation.Methods: Seven hundred participants aged 15-25 years consecutively enrolled in a territory-wide early intervention programme in Hong Kong from July 2001 to August 2003 fulfilled study inclusion criteria, with 539 completing 3-year follow-up. Baseline and follow-up variables were collected via systematic medical file review. The operational criteria for recovery were based on clinical definition incorporating both symptom and functional dimensions.Results: By the end of 3-year follow-up, 58.8% (n = 317) and 17.4% (n = 94) of participants met criteria for symptomatic remission and recovery, respectively. Around half (51.2%, n = 276) were not remitted either symptomatically or functionally in the last 12 months of follow-up. Of those who achieved sustained symptomatic remission, only 43.1% were also in functional remission. Patients in symptomatic remission had lower rate of admissions, shorter duration of hospitalisations and more favourable psychosocial functioning than non-remitted counterparts. Logistic regression analysis revealed that female sex, older age of onset of psychosis, shorter duration of untreated psychosis (DUP) and early symptom resolution predicted symptomatic remission at the end of follow-up. Higher educational attainment, superior baseline occupational status and shorter DUP were found to be predictive of recovery.Conclusion: In a large representative cohort of Chinese young people presenting with first-episode psychosis, although more than half achieved symptomatic remission 3 years after service entry, the rates of functional remission and recovery were low. More intensive psychosocial interventions may be required to further improve patients' functional outcome.
机译：目的：本研究的目的是研究开始治疗后3年出现首发精神病的患者症状缓解和恢复的发生率和预测指标。方法：连续15年至25岁的700名参与者参加了以下研究： 2001年7月至2003年8月在香港进行的广泛的早期干预计划符合研究纳入标准，其中539例完成了为期3年的随访。基线和随访变量通过系统的医学档案审查收集。恢复的手术标准基于包括症状和功能在内的临床定义。结果：到3年随访结束时，有58.8％（n = 317）和17.4％（n = 94）的受试者达到了有症状的缓解和恢复。在随访的最后12个月中，约有一半（51.2％，n = 276）未通过症状或功能缓解。在获得持续症状缓解的患者中，只有43.1％的患者也出现了功能缓解。有症状缓解的患者与未缓解的患者相比，入院率更低，住院时间更短，心理社会功能更佳。 Logistic回归分析显示，女性，精神病发作的年龄较大，未接受治疗的精神病（DUP）的持续时间较短以及早期症状消退可以预测随访结束时症状缓解。研究表明，受过高等教育的人，较高的基线职业状况和较短的DUP可以预示恢复。结论：尽管有一半以上的中国年轻人在服药后3年即达到症状缓解，但其中有一大批具有首次精神病的中国年轻人。功能缓解和恢复率低。可能需要更深入的社会心理干预，以进一步改善患者的功能结局。

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