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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Antipsychotic medication dispensing and associated odds ratios of death in elderly veterans and war widows, 2001.
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Antipsychotic medication dispensing and associated odds ratios of death in elderly veterans and war widows, 2001.

机译：抗精神病药物配药和相关的老年退伍军人和战争遗death死亡几率，2001年。

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OBJECTIVES: To explore the odds ratios (ORs) of death associated with antipsychotic (AP) medications dispensed to elderly subjects. METHOD: Subjects were veterans and war widows 65 years and older dispensed an AP drug in 2001 in NSW or ACT. For all subjects, dispensing records for AP medication, benzodiazepines, lithium, carbamazepine, sodium valproate and antidepressant medication were extracted and combined with age, gender and date of death. A study date was allocated, either the date of death or a random date from 1.5.01 to 31.12.01. Subjects dispensed an AP in 2001, but not dispensed an AP or other psychotropic medication in the 120 days prior to their study date, formed a reference group. Psychotropic dispensing in the 120 days prior to the study date was analysed using nested logistic regression models to produce ORs of death associated with various AP drugs. The ORs for risperidone, olanzapine and pericyazine were compared. Haloperidol ORs were established for those dispensed the drug 0-30 daysprior to study date or 31-120 days prior to the study date. RESULTS: The ORs associated with haloperidol, olanzapine, risperidone, pericyazine, thioridazine and chlorpromazine were significant when compared with the reference group. Odds ratios for all three haloperidol periods were significant when compared with olanzapine, risperidone and pericyazine 120 day ORs. Although there was a trend favouring olanzapine when compared with risperidone, the difference in the ORs failed to reach significance (p=0.066). CONCLUSIONS: Haloperidol is associated with significantly higher mortality rates than other AP medication but it is not clear whether this represents drug toxicity or the medical conditions for which it was dispensed. There was no evidence that the conventional AP pericyazine was associated with a higher mortality rate than olanzapine or risperidone.
机译：目的：探讨与分配给老年受试者的抗精神病药（AP）相关的死亡的比值比（OR）。方法：受试者为65岁以上的退伍军人和战争遗ws，并于2001年在新南威尔士州或ACT分发了AP药物。对于所有受试者，提取了AP药物，苯二氮卓类药物，锂，卡马西平，丙戊酸钠和抗抑郁药的配药记录，并与年龄，性别和死亡日期结合在一起。研究日期被分配，可以是死亡日期，也可以是1.5.01至31.12.01之间的随机日期。受试者于2001年分配了AP，但在研究日期之前的120天内未分配AP或其他精神药物，组成了一个参考组。使用嵌套对数回归模型分析研究日期前120天的精神药物分配，以产生与各种AP药物相关的死亡OR。比较了利培酮，奥氮平和哌嗪的OR。在研究日期之前0-30天或研究日期之前31-120天为分配药物的患者建立了氟哌啶醇OR。结果：与对照组相比，氟哌啶醇，奥氮平，利培酮，哌嗪，硫代哒嗪和氯丙嗪的相关OR值显着。与奥氮平，利培酮和哌嗪嘧啶120天OR相比，所有三个氟哌啶醇时期的赔率均显着。尽管与利培酮相比存在奥氮平的趋势，但OR的差异未达到显着水平（p = 0.066）。结论：氟哌啶醇的死亡率明显高于其他AP药物，但尚不清楚这是否代表药物毒性或所分配的医疗条件。没有证据表明常规的AP周环嗪比奥氮平或利培酮具有更高的死亡率。

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