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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Executive functions in obsessive-compulsive disorder: state or trait deficits?
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Executive functions in obsessive-compulsive disorder: state or trait deficits?

机译：强迫症的执行功能：状态或特质缺陷？

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OBJECTIVE: Despite the neuropsychology literature providing reliable evidence of impaired executive functions in obsessive-compulsive disorder (OCD), to date it has not been determined whether these deficits are trait-related (independent of symptomatology) or state-dependent (dependent on symptomatology). The current research examines the executive functions in OCD in a comprehensive manner and, for the first time, assesses the stability of these deficits over the developmental course of the disorder. METHOD: Using a cross-sectional design, Study 1 examined the executive functions (set shifting, inhibition, planning, verbal fluency and working memory) in 60 subjects (20 actively Symptomatic OCD, 20 Remitted OCD and 20 Panic Disorder). Using a longitudinal design, Study 2 reassessed a subsample of OCD subjects (participants in Study 1) once they reached remitted status. RESULTS: Study 1 found that the OCD groups exhibited deficits in set shifting and inhibition relative to Panic Disorder controls; however, no deficits were observed in planning, verbal fluency or working memory. There were no differences found between the Symptomatic and Remitted OCD groups on any of the executive function measures. Study 2 found that the identified executive function deficits in individuals were stable over time and remained unchanged despite symptom remittance. CONCLUSION: Current results confirm the presence of specific executive function deficits in OCD, and indicate that these deficits are trait-like in nature.
机译：目的：尽管神经心理学文献提供了强迫症（OCD）执行功能受损的可靠证据，但迄今为止，尚未确定这些缺陷是否与特质相关（独立于症状）或状态相关（取决于症状） 。当前的研究以全面的方式检查了强迫症中的执行功能，并且首次评估了这些缺陷在疾病发展过程中的稳定性。方法：采用横断面设计，研究1检查了60名受试者（20名有症状的强迫症，20名缓解的强迫症和20名恐慌症）的执行功能（转移，抑制，计划，口语流利度和工作记忆）。使用纵向设计，研究2在达到缓解状态后重新评估了强迫症受试者（研究1的参与者）的子样本。结果：研究1发现强迫症组相对于恐慌症对照组在集合转移和抑制方面表现出不足;但是，在计划，口语流利度或工作记忆方面没有发现缺陷。有症状和缓解型强迫症组之间在任何执行功能指标上均未发现差异。研究2发现，已确定的个体执行功能缺陷在一段时间内是稳定的，尽管有症状缓解，但仍保持不变。结论：目前的结果证实了强迫症中存在特定的执行功能缺陷，并表明这些缺陷本质上是特质样的。

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