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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Is borderline personality a particularly right hemispheric disorder? A study of P3a using single trial analysis.
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Is borderline personality a particularly right hemispheric disorder? A study of P3a using single trial analysis.

机译：边缘人格是否是特别正确的半球障碍？使用单项试验分析研究P3a。

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OBJECTIVE: To test the hypothesis that borderline personality disorder is a manifestation of a particularly right hemispheric disturbance, involving deficient higher order inhibition, and to consider the therapeutic implications of the findings. METHODS: A cohort of 17 medication free borderline patients were compared with 17 age and sex matched controls by means of a study of p3a, which reflects the activity of one of the two main generators of the P300 (P3) of the event-related-potential. P3b reflects the output of the other generator. P3a, an aspect of the attentional system, depends upon prefrontally connected neurocircuitry. P3b is underpinned by a particularly parietally connected neural system. Using an oddball paradigm, P3a was extracted from the responses to targets using a novel single trial analysis. RESULTS: In borderline patients, over homologous electrode sites, p3a amplitudes, but not latencies, were significantly larger in the right hemisphere compared with the left. The differences were most marked fronto-centrally. No such difference was shown in the control subjects. P3a at right hemisphere sites was significantly larger in borderline compared with control patients. There was no significant difference between the groups for the left hemisphere sites. CONCLUSIONS: The abnormally large amplitudes of P3a at right hemisphere sites in borderline patients together with the failure of habituation of P3a, are consistent with deficient inhibitory activity. Discussion of the findings suggest that they may reflect impeded maturation of the fronto-medial processing systems which, it is argued, may be a consequence of the typical early environment of those with the borderline condition. This suggestion leads to a consideration of optimal therapeutic behaviour in this condition, in particular for 'matching' or 'analogical' responsiveness.
机译：目的：检验边缘性人格障碍是特别右半球障碍的一种表现形式，涉及缺乏高阶抑制作用，并考虑该发现的治疗意义。方法：通过对p3a的研究，将一组17名无药物边界患者与17名年龄和性别匹配的对照进行比较，该研究反映了与事件相关的P300（P3）的两个主要产生因素之一的活动潜在。 P3b反映了另一台发电机的输出。 P3a是注意力系统的一个方面，取决于前额连接的神经回路。 P3b由一个特别是局部连接的神经系统支撑。使用奇异球范式，使用新颖的单次试验分析从对靶标的反应中提取P3a。结果：在边缘患者中，在同源电极部位，右半球的p3a振幅（而不是潜伏期）明显大于左侧。差异最为明显。在对照受试者中未显示出这种差异。与对照组相比，右半球部位的P3a在交界处明显更大。左半球部位的两组之间无显着差异。结论：边缘患者右半球部位P3a的异常大幅度振幅以及P3a的适应性失败与抑制活性不足相符。对这些发现的讨论表明，它们可能反映了额中处理系统的成熟障碍，据认为这可能是那些处于边缘状态的人的典型早期环境的结果。该建议导致考虑在这种情况下的最佳治疗行为，特别是对于“匹配”或“类比”反应性。

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