...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Kava: a comprehensive review of efficacy, safety, and psychopharmacology.
【24h】

Kava: a comprehensive review of efficacy, safety, and psychopharmacology.

机译：卡瓦（Kava）：对功效，安全性和心理药理学的全面综述。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OVERVIEW: Kava (Piper methysticum) is a South Pacific psychotropic plant medicine that has anxiolytic activity. This effect is achieved from modulation of GABA activity via alteration of lipid membrane structure and sodium channel function, monoamine oxidase B inhibition, and noradrenaline and dopamine re-uptake inhibition. Kava is available over the counter in jurisdictions such as the USA, Australia and New Zealand. Due to this, a review of efficacy, safety and clinical recommendations is advised. OBJECTIVE: To conduct a comprehensive review of kava, in respect to efficacy, psychopharmacology, and safety, and to provide clinical recommendations for use in psychiatry to treat generalized anxiety disorder (GAD). METHODS: A review was conducted using the electronic databases MEDLINE, CINAHL, PsycINFO and the Cochrane Library during mid 2010 of search terms relating to kava and GAD. A subsequent forward search was conducted of key papers using Web of Science cited reference search. RESULTS: The current weight of evidence supports the use of kava in treatment of anxiety with a significant result occurring in four out of six studies reviewed (mean Cohen's d = 1.1). Safety issues should however be considered. Use of traditional water soluble extracts of the rhizome (root) of appropriate kava cultivars is advised, in addition to avoidance of use with alcohol and caution with other psychotropic medications. Avoidance of high doses if driving or operating heavy machinery should be mandatory. For regular users routine liver function tests are advised. CONCLUSIONS: While current evidence supports kava for generalized anxiety, more studies are required to assess comparative efficacy and safety (on the liver, cognition, driving, and sexual effects) versus established pharmaceutical comparators.
机译：概述：卡瓦（Piper methysticum）是一种具有抗焦虑活性的南太平洋精神植物药。通过改变脂质膜结构和钠通道功能，单胺氧化酶B抑制以及去甲肾上腺素和多巴胺再摄取抑制，可以调节GABA活性，从而达到这种效果。 Kava在美国，澳大利亚和新西兰等司法管辖区都可以通过柜台购买。因此，建议对功效，安全性和临床建议进行审查。目的：就功效，心理药理学和安全性方面对卡瓦进行全面审查，并提供用于精神病学治疗广泛性焦虑症（GAD）的临床建议。方法：在2010年中使用MEDLINE，CINAHL，PsycINFO和Cochrane图书馆电子数据库对与卡瓦和GAD相关的搜索词进行了审查。随后使用Web of Science引用的参考检索对关键论文进行了正向搜索。结果：目前的证据支持使用卡瓦治疗焦虑症，在所审查的六项研究中有四项取得了显着结果（平均Cohen d = 1.1）。但是，应考虑安全问题。除了避免与酒精一起使用以及谨慎使用其他精神药物外，建议使用适当的卡瓦品种根茎（根）的传统水溶性提取物。如果必须驾驶或操作重型机械，应避免高剂量。对于普通用户，建议常规肝功能检查。结论：尽管目前的证据支持卡瓦广泛性焦虑症，但仍需要进行更多的研究来评估相对于既定的药物比较剂的比较疗效和安全性（在肝脏，认知，驱动和性作用方面）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号