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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Homocysteine level in schizophrenia patients.
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Homocysteine level in schizophrenia patients.

机译：精神分裂症患者的同型半胱氨酸水平。

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OBJECTIVE: Elevated serum levels of homocysteine have been shown to be associated with schizophrenia in some studies, but the evidence is still limited and mixed. The aim of the present study was therefore to evaluate the serum homocysteine level in Chinese in schizophrenia patients and assess its association with clinical phenotypes of the disease. METHOD: A total of 250 inpatients and 250 healthy controls were identified at Kowloon Hospital and the Red Cross Blood Donation Centre, respectively. Each subject was evaluated with a structured diagnostic interview. Demographic data were collected and blood was analysed for homocysteine level. The Positive and Negative Syndrome Scale was used to grade clinical symptoms of schizophrenia. Confounding factors affecting homocysteine levels were controlled by strict exclusion criteria or statistical methods. RESULTS: Serum homocysteine level was elevated in Chinese schizophrenia patients. Both male (mean, 12.26 micromol L(-1); control, 11.40 micromol L(-1), p = 0.026) and female (mean, 9.61 micromol L(-1); control, 8.33 micromol L(-1), p < 0.001) patients had a higher serum homocysteine level than the healthy controls, and these differences persisted after controlling for age. There was no significant association between serum homocysteine level and duration of illness, clinical symptoms or age of onset of schizophrenia. CONCLUSION: The serum homocysteine levels were elevated in both male and female Chinese schizophrenia patients. The levels were not apparently related to other clinical parameters.
机译：目的：一些研究表明，血清高半胱氨酸水平与精神分裂症有关，但证据仍然有限且混杂。因此，本研究的目的是评估精神分裂症患者的中国人血清高半胱氨酸水平，并评估其与该疾病的临床表型的关系。方法：在九龙医院和红十字会献血中心分别确定了250名住院患者和250名健康对照。通过结构化的诊断性访谈对每个受试者进行评估。收集人口统计数据，并分析血液中的同型半胱氨酸水平。阳性和阴性综合征量表用于对精神分裂症的临床症状进行分级。通过严格的排除标准或统计学方法控制影响同型半胱氨酸水平的混杂因素。结果：中国精神分裂症患者血清高半胱氨酸水平升高。男性（平均为12.26 micromol L（-1）;对照为11.40 micromol L（-1），p = 0.026）和女性（平均为9.61 micromol L（-1）;对照为8.33 micromol L（-1）， p <0.001）患者的血清同型半胱氨酸水平高于健康对照组，并且这些差异在控制了年龄之后仍然存在。血清高半胱氨酸水平与疾病持续时间，临床症状或精神分裂症发作年龄之间无显着相关性。结论：中国和男性精神分裂症患者的血清高半胱氨酸水平均升高。该水平显然与其他临床参数无关。

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