The development of charge detection-quadrupole ion trap mass spectrometry driven by rectangular and triangular waves

Xiong C.; Xu G.; Zhou X.; Wang J.; Tang Y.; Chen R.; Peng W.-P.; Chang H.-C.; Nie Z.

首页> 外文期刊>The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry >The development of charge detection-quadrupole ion trap mass spectrometry driven by rectangular and triangular waves

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The development of charge detection-quadrupole ion trap mass spectrometry driven by rectangular and triangular waves

机译：矩形波和三角波驱动的电荷检测四极离子阱质谱研究进展

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In this article, the charge detection quadrupole mass spectrometry (CD-ITMS) driven by rectangular and triangular waveforms (rect-CD-ITMS and tri-CD-ITMS) was developed for the characterization of microparticles. Since the frequency scan of rectangular and triangular waveform could be realized easier than that of sinusoidal waveform, this research intends to provide simpler operation modes for CD-ITMS. In order to demonstrate the feasibility of rect-CD-ITMS and tri-CD-ITMS, the discharge onset voltage, ejection point of analyzed particles, and the achieved mass resolution were analyzed and compared with the case in conventional sinusoidal CD-ITMS (sin-CD-ITMS). The results indicated that the rect-CD-ITMS and tri-CD-ITMS can work well for the mass measurement of microparticles by using frequency scan. Identical mass resolutions were achieved under the same root mean square (RMS) voltage of different waveforms. The mass resolution was further improved by increasing the applied voltage and signal-to-noise ratio (S/N) of charge detector. Moreover, the rect-CD-ITMS and tri-CD-ITMS were applied to characterize red blood cells (RBCs). According to the obtained mean masses and mass distributions, normal and anemic RBCs were distinguished successfully. This journal is

机译：在本文中，开发了由矩形和三角波（rect-CD-ITMS和tri-CD-ITMS）驱动的电荷检测四极质谱（CD-ITMS），用于表征微粒。由于矩形和三角形波形的频率扫描比正弦波形的频率扫描更容易实现，因此本研究旨在为CD-ITMS提供更简单的操作模式。为了证明rect-CD-ITMS和tri-CD-ITMS的可行性，分析了放电起始电压，被分析颗粒的喷射点和达到的质量分辨率，并与常规正弦CD-ITMS（正弦波）进行了比较。 -CD-ITMS）。结果表明，rect-CD-ITMS和tri-CD-ITMS通过频率扫描可以很好地用于微粒的质量测量。在不同波形的相同均方根（RMS）电压下获得了相同的质量分辨率。通过增加施加电压和电荷检测器的信噪比（S / N），可以进一步提高质量分辨率。此外，将rect-CD-ITMS和tri-CD-ITMS用于表征红细胞（RBC）。根据获得的平均质量和质量分布，成功地区分了正常和贫血的红细胞。这本日记是

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《The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry》 |2012年第5期|共6页
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Xiong C.; Xu G.; Zhou X.; Wang J.; Tang Y.; Chen R.; Peng W.-P.; Chang H.-C.; Nie Z.;
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1. The development of charge detection-quadrupole ion trap mass spectrometry driven by rectangular and triangular waves [J] . Xiong C., Xu G., Zhou X., The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry . 2012,第5期

机译：矩形波和三角波驱动的电荷检测四极离子阱质谱研究进展
2. A gated trapping strategy with a two-time constant and a delay for catching in-field generated ions that range over three decades in mass-to-charge and two decades in velocity in Fourier-transform mass spectrometry [J] . Rempel DL., Gross ML. Journal of the American Society for Mass Spectrometry . 2001,第3期

机译：具有两次常数和延迟的门控捕获策略，用于捕获场内产生的离子，在傅里叶变换质谱法中质荷比范围超过三十年，速度在几十年范围内
3. Mapping the stability diagram of a digital ion trap (DIT) mass spectrometer varying the duty cycle of the trapping rectangular waveform [J] . Berton A, Traldi P, Ding L, Journal of the American Society for Mass Spectrometry . 2008,第4期

机译：映射数字离子阱（DIT）质谱仪的稳定性图以改变捕获矩形波形的占空比
4. Computer Modeling of Trapped-Ion Cell Capacitance for Optimization of Ion Image Charge Detection Mass Spectrometry [C] . Steven C. Beu, Nathan K. Kaiser, Donald F. Smith, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：捕获离子电池电容的计算机建模，用于优化离子图像电荷检测质谱法
5. Development of a novel mass-selected internal positive chemical ionization quadrupole ion trap mass spectrometry technique for the quantitative analysis of isotopic polyunsaturated fatty acids. [D] . Izadi, Hamid. 2009

机译：开发用于同位素多不饱和脂肪酸定量分析的新型质量选择内部正化学电离四极杆离子阱质谱技术。
6. Comprehensive characterisation of the heterogeneity of adalimumab via charge variant analysis hyphenated on-line to native high resolution Orbitrap mass spectrometry [O] . Florian Füssl, Anne Trappe, Ken Cook, 2019

机译：通过在线连接到天然高分辨率Orbitrap质谱的电荷变异分析对阿达木单抗的异质性进行全面表征
7. A gated trapping strategy with a two-time constant and a delay for catching in-field generated ions that range over three decades in mass-to-charge and two decades in velocity in fourier-transform mass spectrometry [O] . Rempel D.L, Gross M.L 2001

机译：具有两次常数和延迟的门控捕获策略，用于捕获场内生成的离子，其质荷比范围超过三十年，傅立叶变换质谱法的范围超过二十年
8. EBIT in the Magnetic Trapping Mode: Mass Spectrometry, Atomic Lifetime Measurements, and Charge Transfer Reactions of Highly Charged Atomic Ions. [R] . Schweikhard, L., Beiersdorfer, P., Traebert, E. 2002

机译：磁捕获模式中的EBIT：质谱，原子寿命测量和高电荷原子离子的电荷转移反应。

The development of charge detection-quadrupole ion trap mass spectrometry driven by rectangular and triangular waves

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