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首页> 外文期刊>The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry >Broadscale resolving power performance of a high precision uniform field ion mobility-mass spectrometer
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Broadscale resolving power performance of a high precision uniform field ion mobility-mass spectrometer

机译：高精度均匀场离子迁移率质谱仪的宽分辨能力性能

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摘要

An extensive study of two current ion mobility resolving power theories ("conditional" and "semi-empirical") was undertaken using a recently developed drift tube ion mobility-mass spectrometer. The current study investigates the quantitative agreement between experiment and theory at reduced pressure (4 Torr) for a wide range of initial ion gate widths (100 to 500 mu s), and ion mobility values (K-0 from 0.50 to 3.0 cm(2) V-1 s(-1)) representing measurements obtained in helium, nitrogen, and carbon dioxide drift gas. Results suggest that the conditional resolving power theory deviates from experimental results for low mobility ions (e.g., high mass analytes) and for initial ion gate widths beyond 200 mu s. A semi-empirical resolving power theory provided close-correlation of predicted resolving powers to experimental results across the full range of mobilities and gate widths investigated. Interpreting the results from the semi-empirical theory, the performance of the current instrumentation was found to be highly linear for a wide range of analytes, with optimal resolving powers being accessible for a narrow range of drift fields between 14 and 17 V cm(-1). While developed using singly-charged ion mobility data, preliminary results suggest that the semi-empirical theory has broader applicability to higher-charge state systems.
机译：使用最近开发的漂移管离子迁移率质谱仪对两种当前的离子迁移率分辨能力理论（“有条件的”和“半经验的”）进行了广泛的研究。当前的研究调查了在大范围的初始离子门宽度（100至500μs）和离子迁移率值（K-0从0.50至3.0 cm（2） ）V-1 s（-1））表示在氦气，氮气和二氧化碳漂移气体中获得的测量值。结果表明，对于低迁移率离子（例如高质量分析物）和超过200μs的初始离子门宽度，条件分辨力理论与实验结果有所不同。半经验分辨力理论在整个迁移率和门宽范围内提供了预测分辨力与实验结果的紧密相关性。解释半经验理论的结果，发现当前仪器的性能对多种分析物具有高度线性，对于14至17 V cm（-）的窄范围漂移场，可获得最佳分辨能力1）。当使用单电荷离子迁移率数据进行开发时，初步结果表明，半经验理论对高电荷态系统具有更广泛的适用性。

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