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首页> 外文期刊>The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry >Resolving powers of > 7900 using linked scans: how well does resolving power describe the separation capability of differential ion mobility spectrometry
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Resolving powers of > 7900 using linked scans: how well does resolving power describe the separation capability of differential ion mobility spectrometry

机译：使用链接扫描获得的> 7900的分辨力：分辨力描述差动离子迁移谱法分离能力的程度如何

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摘要

Differential ion mobility spectrometry (DIMS) separations are described using similar terminology to liquid chromatography, capillary electrophoresis, and drift tube ion mobility spectrometry. The characterization and comparison of all these separations are typically explained in terms of resolving power, resolution, and/or peak capacity. A major difference between these separations is that DIMS separations are in space whereas the others are separations in time. However, whereas separations in time can, in theory, be extended infinitely, separations in space, such as DIMS separations, are constrained by the physical dimensions of the device. One method to increase resolving power of DIMS separations is to use helium in the DIMS carrier gas. However, ions have a greater mobility in helium which causes more ions to be neutralized due to collisions with the DIMS electrodes or electrode housing, i.e. the space constraints. This neutralization of ions can lead to the loss of an entire peak, or peaks, from a DIMS scan. To take advantage of the benefits of helium use while reducing ion losses, linked scans were developed. During a linked scan the amount of helium present in the DIMS carrier gas is decreased as the compensation field is increased. A comparison of linked scans to compensation field scans with constant helium is presented herein. Resolving powers >7900 are obtained with linked scans. However, this result highlights the limitation of using resolving power as a metric to describe DIMS separations.
机译：使用与液相色谱，毛细管电泳和漂移管离子迁移谱类似的术语描述了差分离子迁移谱（DIMS）分离。通常根据分离能力，分离度和/或峰容量说明所有这些分离的表征和比较。这些分隔之间的主要区别在于DIMS分隔是在空间中，而其他分隔是时间上的分隔。然而，尽管时间上的间隔在理论上可以无限扩展，但是空间上的间隔（例如DIMS间隔）受到设备物理尺寸的限制。增加DIMS分离能力的一种方法是在DIMS载气中使用氦气。但是，离子在氦气中具有较大的迁移率，由于与DIMS电极或电极外壳的碰撞，即空间限制，导致更多的离子被中和。离子的这种中和作用可能导致DIMS扫描损失整个一个或多个峰。为了利用氦气使用的好处，同时减少离子损失，开发了链接扫描。在链接扫描期间，随着补偿场的增加，DIMS载气中存在的氦气量会减少。本文介绍了链接扫描与具有恒定氦气的补偿场扫描的比较。通过链接扫描可获得> 7900的分辨力。但是，此结果凸显了使用分辨力作为度量DIMS分离的度量标准的局限性。

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