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首页> 外文期刊>The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry >A two-phase approach to fourier transform ion mobility time-of-flight mass spectrometry
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A two-phase approach to fourier transform ion mobility time-of-flight mass spectrometry

机译：傅里叶变换离子迁移率飞行时间质谱的两阶段方法

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摘要

It is well known that the duty cycle of common drift-tube ion mobility experiments is often below 1%. However, multiplexing approaches such as Fourier and Hadamard pulsing schemes have been shown to independently enhance the throughput of ion mobility spectrometry (IMS) experiments to levels that approach 50%. While challenges remain to their broad scale implementation we describe a new Fourier transform (FT) IMS experiment that is directly compatible with standard drift tube ion mobility mass spectrometers (DT-IMMS). Compared to previous FT-IMS experiments, our new approach requires only a single gate and circumvents the need for signal apodization by combining data from two frequency pulsing sequences 180 degrees out of phase. Assessment of our initial results highlights an increase in signal-to-noise (SNR) relative to both previous implementations FT-IMS experiments and signal averaged (SA) experiments. For select tetraalkylammonium salts SNR improvements of more than one order of magnitude are routinely possible. To explore the performance metrics associated with the technique a number of experimental variables were systematically altered including frequency sweep range, sweep time, and data acquisition time. Using this experimental design we present the key aspects, considerations, and minimum resources necessary for other IMS researchers to incorporate this operational mode into their research. The two-phase FT-IMMS technique offers a tractable mechanism to enhance sensitivity for IMMS measurements and its broad-scale adoption by IMMS researchers promises to enhance the acquisition speed for mobility measurements using hybrid instrumentation.
机译：众所周知，普通漂移管离子迁移率实验的占空比通常低于1％。但是，已经证明诸如傅立叶和哈达玛脉冲方案之类的多路复用方法可以独立地将离子迁移谱（IMS）实验的吞吐量提高到接近50％的水平。虽然在大规模实施方面仍然存在挑战，但我们描述了一种新的傅立叶变换（FT）IMS实验，该实验与标准漂移管离子迁移质谱仪（DT-IMMS）直接兼容。与以前的FT-IMS实验相比，我们的新方法仅需一个门，并且通过组合两个相位差为180度的频率脉冲序列的数据来避免信号变迹。对我们初始结果的评估突出表明，相对于以前的FT-IMS实验和信号平均（SA）实验，信噪比（SNR）都有所提高。对于选择的四烷基铵盐，通常可以将SNR提高一个数量级以上。为了探索与该技术相关的性能指标，系统地更改了许多实验变量，包括频率扫描范围，扫描时间和数据采集时间。使用该实验设计，我们介绍了其他IMS研究人员将这种操作模式纳入其研究所需的关键方面，注意事项和最少的资源。两阶段FT-IMMS技术提供了一种易于处理的机制，可以提高IMMS测量的灵敏度，IMMS研究人员广泛采用该技术有望提高使用混合仪器进行移动性测量的采集速度。

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