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首页> 外文期刊>The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry >Intraoperative detection of liver tumors aided by a fluorescence goggle system and multimodal imaging
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Intraoperative detection of liver tumors aided by a fluorescence goggle system and multimodal imaging

机译：荧光镜系统和多模态成像辅助的肝肿瘤术中检测

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摘要

Real-time image guidance in the operating room is needed to improve instantaneous surgical decisions. Toward this goal, we utilized a new fluorescence goggle system and a near-infrared fluorescent dye approved for human use, indocyanine green, to demonstrate the feasibility of detecting liver tumors intraoperatively. The fluorescence goggle provided successful imaging of multifocal breast cancer metastases in mouse liver. Diffused tumor deposits as small as 0.8 mm in diameter were detected, which were not obvious without the fluorescence goggle. A combination of surfaceweighted fluorescence imaging and deep tissue-sensitive ultrasound imaging allowed comprehensive image guidance with the fluorescence goggle system for tumor resection in a rabbit VX2 liver metastasis model. This multimodal detection and guided surgical intervention strategy using ultrasonic imaging and real-time intraoperative fluorescence guidance is a promising and innovative technology platform for improving surgical outcome of human patients with primary or metastatic liver cancer.
机译：需要在手术室中进行实时图像引导以改善即时手术决策。为了实现这一目标，我们利用了一种新型的荧光镜系统和一种批准用于人类的近红外荧光染料吲哚菁绿，来证明在术中检测肝脏肿瘤的可行性。荧光镜可为小鼠肝脏多灶性乳腺癌转移提供成功的成像。检测到直径仅为0.8 mm的扩散肿瘤沉积物，如果没有荧光镜则不明显。在兔VX2肝转移模型中，表面加权荧光成像和深层组织敏感的超声成像相结合，可以利用荧光镜系统对肿瘤切除术进行全面的图像指导。这种使用超声成像和实时术中荧光引导的多模式检测和指导性手术干预策略，是一种有前途的创新技术平台，可以改善人类原发性或转移性肝癌患者的手术效果。

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