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首页> 外文期刊>The Australian Journal of Pharmacy >The risk of some birth defects increased by folic acid antagonists during pregnancy
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The risk of some birth defects increased by folic acid antagonists during pregnancy

机译：叶酸拮抗剂在怀孕期间增加某些先天缺陷的风险

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摘要

IT is widely accepted that the use of folic acid, either alone or as an ingredient in multivitamin supplements, both prior to delivery and during the first trimester, reduces the risk of women having an infant with a neural-tube defect.It is not so widely known that multivitamin supplements that contain folic acid, taken prior to and during pregnancy, may also reduce the risks of cardiovascular defects, oral clefts, urinary tract defects, and limb-reduction defects, in their infants. However, it is not clear whether folic acid or some other component in the multivitamins is responsible for these reductions in risk, since most multivitamins contain more than 15 vitamins and minerals.It has been postulated that one way to assess the role of the folic acid component of multivitamins in decreasing the prevalence of birth defects is to determine whether folic acid antagonists are associated with an increased risk of such defects.l There are two general groups of folic acid antagonists.One group consists of the dihydrofolate reductase inhibitors, which displace folate from the enzyme and, thereby, block the conversion of folate to its more active metabolites.
机译：IT已被广泛接受，无论是在分娩前还是在孕早期，单独使用叶酸或将其作为多种维生素补充剂的成分使用，都可以降低女性患神经管缺陷婴儿的风险。众所周知，在怀孕之前和怀孕期间服用的含有叶酸的多种维生素补充剂，还可降低婴儿患心血管疾病，口腔裂口，尿路缺陷和四肢复位缺陷的风险。但是，目前尚不清楚叶酸或多种维生素中的其他成分是否会导致这些风险的降低，因为大多数多种维生素都包含15种以上的维生素和矿物质。据推测，评估叶酸作用的一种方法是降低出生缺陷患病率的多种维生素的组成部分是确定叶酸拮抗剂是否与此类缺陷的风险增加相关。l叶酸拮抗剂一般分为两类。一类是由二氢叶酸还原酶抑制剂组成，它们取代叶酸。从酶中分离出来，从而阻止叶酸转化为其活性更高的代谢产物。

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