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首页> 外文期刊>Biochemistry and Cell Biology >Differential enrichment of TTF-I and Tip5 in the T-like promoter structures of the rDNA contribute to the epigenetic response of Cyprinus carpio during environmental adaptation
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Differential enrichment of TTF-I and Tip5 in the T-like promoter structures of the rDNA contribute to the epigenetic response of Cyprinus carpio during environmental adaptation

机译：rDNA T样启动子结构中TTF-1和Tip5的差异富集有助于鲤鱼在环境适应过程中的表观遗传反应

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摘要

To ensure homeostasis, ectothermic organisms adapt to environmental variations through molecular mechanisms. We previously reported that during the seasonal acclimatization of the common carp Cyprinus carpio, molecular and cellular functions are reprogrammed, resulting in distinctive traits. Importantly, the carp undergoes a drastic rearrangement of nucleolar components during adaptation. This ultrastructural feature reflects a fine modulation of rRNA gene transcription. Specifically, we identified the involvement of the transcription termination factor I (TTF-I) and Tip-5 (member of nucleolar remodeling complex, NoRC) in the control of rRNA transcription. Our results suggest that differential Tip5 enrichment is essential for silencing carp ribosomal genes and that the T-0 element is key for regulating the ribosomal gene during the acclimatization process. Interestingly, the expression and content of Tip5 were significantly higher in winter than in summer. Since carp ribosomal gene expression is lower in the winter than in summer, and considering that expression concomitantly occurs with nucleolar ultrastructural changes of the acclimatization process, these results indicate that Tip5 importantly contributes to silencing the ribosomal genes. In conclusion, the current study provides novel evidence on the contributions of TTF-I and NoRC in the environmental reprogramming of ribosomal genes during the seasonal adaptation process in carp.
机译：为了确保体内平衡，外热生物通过分子机制适应环境变化。我们以前曾报道过，在鲤鱼的季节性适应过程中，对鲤鱼的分子和细胞功能进行了重新编程，从而产生了独特的性状。重要的是，鲤鱼在适应过程中经历了核仁成分的剧烈重排。这种超微结构特征反映了rRNA基因转录的精细调节。具体来说，我们确定了转录终止因子I（TTF-1）和Tip-5（核仁重塑复合体，NoRC的成员）在rRNA转录控制中的参与。我们的结果表明，差异化的Tip5富集对于沉默鲤鱼核糖体基因必不可少，而T-0元件是在驯化过程中调节核糖体基因的关键。有趣的是，冬季中Tip5的表达和含量明显高于夏季。由于冬季冬季鲤鱼核糖体基因表达低于夏季，并且考虑到该表达与适应过程的核仁超微结构变化同时发生，因此这些结果表明Tip5对沉默核糖体基因起重要作用。总之，当前的研究提供了有关TTF-1和NoRC在鲤鱼季节适应过程中对核糖体基因进行环境重编程的贡献的新证据。

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