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首页> 外文期刊>The American surgeon. >The Impact of Chemotherapy on Complications Associated with Mastectomy and Immediate Autologous Tissue Reconstruction
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The Impact of Chemotherapy on Complications Associated with Mastectomy and Immediate Autologous Tissue Reconstruction

机译：化学疗法对乳房切除术和立即自体组织重建相关并发症的影响

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摘要

We performed this study to evaluate the impact of chemotherapy on the outcomes associated with immediate autologous tissue reconstruction (IATR) in the treatment of breast cancer. Patients were divided into two groups: Group 1 received chemotherapy before surgery and Group 2 did not receive chemotherapy. Records were reviewed to identify demographics, comorbidities, histology, and wound healing complications. Groups were compared using Kruskal-Wallis and Fisher exact tests as appropriate. A total of 128 patients were identified: 29 received chemotherapy before surgery (Group 1) and 99 did not receive chemotherapy (Group 2). Group 1 patients were more likely to have diabetes 27 per cent versus 6 per cent (P = 0.005) despite both groups having a mean body mass index of 30. Group 2 patients had less advanced stage disease as expected because they did not receive chemotherapy; 37 per cent of Group 2 patients had stage 0 breast cancer (P < 0.001). The incidence of wound complications was 17 per cent in Group 1 and 12 per cent in Group 2 (P = NS). Preoperative chemotherapy for breast cancer followed by IATR was associated with no increased risk of healing complications. IATR can be offered to patients who require preoperative chemotherapy, and their healing will not be impaired as a result of the chemotherapy.
机译：我们进行了这项研究，以评估化学疗法对乳腺癌治疗中与立即自体组织重建（IATR）相关的结局的影响。患者分为两组：第一组在手术前接受化学疗法，第二组未接受化学疗法。审查记录以识别人口统计学，合并症，组织学和伤口愈合并发症。适当时使用Kruskal-Wallis和Fisher精确检验比较各组。总共鉴定出128位患者：29位在手术前接受了化疗（第1组）和99位未接受了化疗（第2组）。尽管两组的平均体重指数均为30，但第一组患者患糖尿病的可能性更高，分别为27％和6％（P = 0.005）。第二组患者由于未接受化疗而未达到预期的晚期疾病。第2组患者中有37％患有0期乳腺癌（P <0.001）。第1组的伤口并发症发生率为17％，第2组的伤口并发症发生率为12％（P = NS）。乳腺癌的术前化学疗法后再行IATR不会增加治愈并发症的风险。 IATR可以提供给需要术前化疗的患者，并且化疗不会损害他们的康复。

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