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首页> 外文期刊>The Americas Journal of Plant Science and Biotechnology >Understanding Plants Modified by Transgenesis Using High-Throughput Profiling Technologies and the Relevance for their Regulation in Canada
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Understanding Plants Modified by Transgenesis Using High-Throughput Profiling Technologies and the Relevance for their Regulation in Canada

机译：了解使用高通量分析技术进行转基因修饰的植物及其在加拿大调控的相关性

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摘要

Unintended effects can occur in transgenic plants through interactions between genetic elements at the site of insertion or through interactions between the introduced gene and endogenous plant processes. High through-put profiling technologies have been applied to identify unintended effects in transgenic plants and have provided insight into their nature and extent. These studies have revealed that the process of transgenesis is not universally disruptive to plants and does not necessarily produceunintended effects. In contrast, there is often significant variability in the profiles of plants that have been developed using conventional breeding techniques, suggesting that transgenesis is no more likely to produce unintended effects than these other breeding approaches. The nature of the transgene is likely to be the most important factor that determines the extent of unintended effects that occur in transgenic plants, although there is some evidence that even genes that alter transcriptional networks may not introduce unintended effects. These observations support Canada's unique regulatory approach, which is based on the presence of a novel trait as opposed to the process of transgenesis. This greater understanding of unintended effects in transgenic plants can also help further shape the regulatory system by guiding the allocation of resources to those transgenic plants that represent the greatest risk.
机译：通过插入位点的遗传元件之间的相互作用或通过引入的基因与内源植物过程之间的相互作用，在转基因植物中可能发生意想不到的影响。高通量分析技术已应用于鉴定转基因植物中的意外影响，并提供了对其性质和程度的了解。这些研究表明，转基因过程并不普遍破坏植物，并不一定会产生意想不到的影响。相比之下，使用常规育种技术开发的植物的概况通常存在很大差异，这表明转基因比其他育种方法更不可能产生意想不到的效果。转基因的性质可能是决定转基因植物中发生意想不到的影响程度的最重要因素，尽管有一些证据表明，即使改变转录网络的基因也可能不会引入意想不到的影响。这些观察结果支持加拿大独特的监管方法，该方法基于与转基因过程相反的新性状的存在。对转基因植物中意想不到的影响的更多了解还可以通过指导将资源分配给代表最大风险的那些转基因植物来帮助进一步塑造调控系统。

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