Duration of Efficacy of Ceftiofur Crystalline Free Acid Compared to Tilmicosin When Administered at Various Times before Intratracheal Mannheimia haemolytica Challenge in Calves

E.J. Robb; B. Hibbard; S.L. Follis; W.L. Bryson; K.J. Dame; M.J. Lucas; T.N. TerHune

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Duration of Efficacy of Ceftiofur Crystalline Free Acid Compared to Tilmicosin When Administered at Various Times before Intratracheal Mannheimia haemolytica Challenge in Calves

机译：犊牛气管内溶血曼海姆氏菌攻击前不同时间给药头孢噻呋结晶游离酸与替米考星相比的疗效持续时间

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The primary objective of this study was to evaluate the duration of protection provided against bovine respiratory disease (BRD) by ceftiofur crystalline free acid sterile suspension (CCFA-SS; 200 mg ceftiofur equivalents [CE]/mL) administered as a single injection subcutaneously (SC) in the middle third of the posterior aspect of the ear of calves compared to tilmicosin. Treatments were administered at 3, 5, 7, or 9 days before intratracheal challenge with Mannheimia haemolytica. Secondary objectives included determining plasma ceftiofur and desfuroylceftiofur-related metabolite concentrations and serum haptoglobin concentrations at various predetermined times.

机译：这项研究的主要目的是评估皮下注射一次注射头孢噻呋结晶游离酸无菌混悬液（CCFA-SS; 200 mg头孢噻呋当量[CE] / mL）对牛呼吸道疾病（BRD）的保护持续时间（与替米考星相比，位于小牛耳朵后部中间三分之一的位置）。在用溶血曼海姆氏菌进行气管内攻击之前的3、5、7或9天进行治疗。次要目标包括在各个预定时间确定血浆头孢噻呋和与呋喃头孢呋喃有关的代谢物浓度以及血清触珠蛋白浓度。

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《The Bovine Practitioner》 |2004年第2期|共1页
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E.J. Robb; B. Hibbard; S.L. Follis; W.L. Bryson; K.J. Dame; M.J. Lucas; T.N. TerHune;
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中图分类动物医学（兽医学）;
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1. Duration of Efficacy of Ceftiofur Crystalline Free Acid Compared to Tilmicosin When Administered at Various Times before Intratracheal Mannheimia haemolytica Challenge in Calves [J] . E.J. Robb, B. Hibbard, S.L. Follis, The Bovine Practitioner . 2004,第2期

机译：犊牛气管内溶血曼海姆氏菌攻击前不同时间给药头孢噻呋结晶游离酸与替米考星相比的疗效持续时间
2. Comparative efficacy of ceftiofur crystalline free acid and florfenicol-flunixin meglumine for undifferentiated fever treatment in feedlot calves administered tulathromycin metaphylactically on arrival [J] . Eric J. Behlke, Sherry J. Harmon, Tye Perrett, The Bovine Practitioner . 2015,第1期

机译：头孢噻呋结晶性游离酸和氟苯尼考氟尼辛葡甲胺在到达途中经代谢性施用图拉霉素的育肥牛犊未分化发热的比较疗效
3. Duration of efficacy of ceftiofur crystalline free acid sterile suspension against clinical disease in grower pigs challenged with Actino bacillus pleuropneumoniae [J] . John P. Crane, W. Lawrence Bryson, Young C. Anderson, Journal of Swine Health and Production . 2006,第6期

机译：Ceftiofur结晶酸性无菌悬浮液对种植猪临床疾病的疗效验询攻击患者患有Actino Bacillus Pleuropneumoniae
4. Penetration of Ceftiofur into Sterile versus Mannheimia Haemolytica-Intected Tissue Chambers in Beef Calves after Subcutaneous Administration of Ceftiofur Crystalline Free Acid Sterile Suspension in the Ear Pinna [C] . K.E. Washburn, R. Johnson, C.R. Clarke, Annual Conference of American Association of Bovine Practitioners . 2004

机译：在皮下施用头孢噻呋晶reled酸无菌悬浮液中，将头孢噻呋酯与Mannheimia Haemolytica inclated Compent Coment Comented Coys-Charence在耳廓上的耳廓晶体中进行
5. Pharmacokinetics of ceftiofur crystalline free acid in pigs vaccinated against, challenged with, or vaccinated against and challenged with PRRSv. [D] . Sparks, Joel W. 2015

机译：头孢噻呋结晶游离酸在接种PRRSv疫苗，用PRRSv攻击，或用PRRSv接种和攻击的猪中的药代动力学。
6. Determination of the Duration of Antibacterial Efficacy following Administration of Gamithromycin Using a Bovine Mannheimia haemolytica Challenge Model [O] . A. B. Forbes, C. Ramage, J. Sales, 2011

机译：使用牛溶血性曼海姆氏菌攻击模型确定加米霉素给药后的抗菌功效持续时间
7. Pre-weaning plane of nutrition and Mannheimia haemolytica dose influence inflammatory responses to a bovine herpesvirus-1 and Mannheimia haemolytica challenge in post-weaning Holstein calves [O] . K.P. Sharon, Y. Liang, N. C. Burdick Sanchez, 2019

机译：营养预防平面和曼海姆米米醇溶解剂量会影响牛疱疹病毒-1和断奶后荷斯坦小牛的牛疱疹病毒-1和Mannheimia Haemolytica挑战的炎症反应

Duration of Efficacy of Ceftiofur Crystalline Free Acid Compared to Tilmicosin When Administered at Various Times before Intratracheal Mannheimia haemolytica Challenge in Calves

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