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首页> 外文期刊>The Breast : >Survivin and COX-2 expression in male breast carcinoma.
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Survivin and COX-2 expression in male breast carcinoma.

机译：Survivin和COX-2在男性乳腺癌中的表达。

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Male breast carcinoma (Male BC) is a distinct biological subtype of breast cancer. We previously reported an association between 5-year overall survival and strong intratumoral aromatase (ITA) expression in Male BC. In this study, we investigate survivin and COX-2 expression and their relationship to ITA. Clinical data were abstracted for all Male BC patients diagnosed between 1985 and 2005 in Nova Scotia, Canada. Archival tissues were retrieved for tissue microarray (TMA) and immunohistochemistry (IHC). Of 54 Male BCs identified, 39 cases had tissue available for IHC. Survivin expression was noted in 27 cases (69%); 12 nuclear and 26 cytoplasmic while strong COX-2 expression was observed in 14 cases (36%). Cytoplasmic survivin and COX-2 expressions were positively associated with ITA expression. However, survivin and COX-2 expression were not predictive of survival. Additional studies are needed to further elucidate the correlation between cytoplasmic survivin, COX-2 and ITA expression in Male BC considering their potential therapeutic implications.
机译：男性乳腺癌（Male BC）是乳腺癌的一种独特的生物学亚型。我们先前曾报道男性BC中5年总生存率与强大的瘤内芳香化酶（ITA）表达之间存在关联。在这项研究中，我们调查了survivin和COX-2的表达及其与ITA的关系。对加拿大新斯科舍省1985年至2005年期间诊断出的所有男性BC患者的临床数据进行了摘要。检索档案组织用于组织微阵列（TMA）和免疫组织化学（IHC）。在确定的54例男性BC中，有39例具有可用于IHC的组织。在27例患者中观察到了survivin表达（69％）; 14例（36％）观察到12个核和26个细胞质，而COX-2表达强。细胞质survivin和COX-2的表达与ITA的表达呈正相关。但是，survivin和COX-2的表达不能预测生存。考虑到它们潜在的治疗意义，还需要进一步的研究来进一步阐明男性BC中胞浆存活蛋白，COX-2和ITA表达之间的相关性。

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