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首页> 外文期刊>The British journal of psychiatry : >Escitalopram and paroxetine in the treatment of generalised anxiety disorder: randomised, placebo-controlled, double-blind study.
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Escitalopram and paroxetine in the treatment of generalised anxiety disorder: randomised, placebo-controlled, double-blind study.

机译：艾司西酞普兰和帕罗西汀治疗广泛性焦虑症：随机，安慰剂对照，双盲研究。

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BACKGROUND: It is uncertain whether higher doses of selective serotonin reuptake inhibitors have greater efficacy in generalised anxiety disorder. AIMS: To assess the efficacy of different doses of escitalopram in generalised anxiety disorder. METHOD: Randomised, double-blind, placebo-controlled, fixed-dose, parallel-group, 12-week study, with 681 patients: placebo (n=139); escitalopram, 5 mg/day, (n=134); 10 mg/day (n=136); 20 mg/day (n=133); paroxetine, 20 mg/day (n=139). RESULTS: Mean change in the primary efficacy measure was greater with escitalopram 10 and 20 mg than with placebo; 10 mg was more efficacious than paroxetine. Paroxetine was superior to placebo on some secondary measures, at some time points. Compared with placebo, more patients withdrew because of adverse events with escitalopram 20 mg and paroxetine. CONCLUSIONS: Escitalopram was efficacious in generalised anxiety disorder, 20 was not significantly superior to 10 mg/day. Escitalopram 10 mg was more efficacious than paroxetine.
机译：背景：尚不确定高剂量的选择性5-羟色胺再摄取抑制剂在广泛性焦虑症中是否具有更大的疗效。目的：评估不同剂量的依他普仑治疗广泛性焦虑症的疗效。方法：随机，双盲，安慰剂对照，固定剂量，平行组，12周研究，共681例患者：安慰剂（n = 139）;安慰剂组（n = 139）。依他普仑5毫克/天，（n = 134）; 10毫克/天（n = 136）; 20毫克/天（n = 133）;帕罗西汀20毫克/天（n = 139）。结果：依他普仑10和20 mg的主要疗效指标的平均变化大于安慰剂。 10 mg比帕罗西汀更有效。在某些时间点上，帕罗西汀在某些次要措施上优于安慰剂。与安慰剂相比，使用艾司西酞普兰20 mg和帕罗西汀的不良事件导致更多的患者退出。结论：艾司西酞普兰对广泛性焦虑症有效，20毫克/天不明显优于10毫克/天。 Escitalopram 10 mg比paroxetine更有效。

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