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首页> 外文期刊>The British journal of psychiatry : >Strategies for discontinuing long-term benzodiazepine use: meta-analysis.
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Strategies for discontinuing long-term benzodiazepine use: meta-analysis.

机译：长期停用苯二氮卓类药物的策略：荟萃分析。

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BACKGROUND: The prevalence of benzodiazepine consumption in European countries remains at 2-3% of the general population despite the well-documented disadvantages of long-term use. AIMS: To review systematically the success rates of different benzodiazepine discontinuation strategies. METHOD: Meta-analysis of comparable intervention studies. RESULTS: Twenty-nine articles met inclusion criteria. Two groups of interventions were identified; minimal intervention (e.g. giving simple advice in the form of a letter or meeting to a large group of people; n=3), and systematic discontinuation (defined as treatment programmes led by a physician or psychologist; n=26). Both were found to be significantly more effective than treatment as usual: minimal interventions (pooled OR=2.8, 95% CI 1.6-5.1); systematic discontinuation alone (one study, OR=6.1, 95% CI 2.0-18.6). Augmentation of systematic discontinuation with imipramine (two studies, OR=3.1, 95% CI 1.1-9.4) or group cognitive-behavioural therapy for patientswith insomnia (two studies, OR=5.5, 95% CI 2.3-14.2) was superior to systematic discontinuation alone. CONCLUSIONS: Evidence was found for the efficacy of stepped care (minimal intervention followed by systematic discontinuation alone) in discontinuing long-term benzodiazepine use.
机译：背景：尽管有充分的证据证明长期使用不利，但欧洲国家的苯二氮卓类消费量仍占总人口的2-3％。目的：系统评价不同苯二氮卓类药物停用策略的成功率。方法：可比干预研究的荟萃分析。结果：29篇文章符合纳入标准。确定了两组干预措施;最少的干预（例如以信件或与大群人见面的形式提供简单建议; n = 3）和系统性停药（定义为由医生或心理学家主导的治疗方案; n = 26）。两种方法均比常规治疗有效得多：最少干预（合并OR = 2.8，95％CI 1.6-5.1）;单独进行系统停药（一项研究，OR = 6.1，95％CI 2.0-18.6）。用丙咪嗪（两项研究，OR = 3.1，95％CI 1.1-9.4）或小组认知行为疗法增强失眠患者的系统性终止（两项研究，OR = 5.5，95％CI 2.3-14.2）优于系统性终止单独。结论：有证据表明逐步护理（最小干预，然后单独系统性停药）在中止长期使用苯二氮卓类药物方面的有效性。

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