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首页> 外文期刊>The British journal of psychiatry : >Reduction of the parahippocampal gyrus and the hippocampus in patients with chronic schizophrenia.
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Reduction of the parahippocampal gyrus and the hippocampus in patients with chronic schizophrenia.

机译：慢性精神分裂症患者海马旁回和海马的减少。

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BACKGROUND: There have been many studies reporting reduced volume of the hippocampus or other limbic structures in patients with schizophrenia, but the literature is inconsistent. AIMS: To compare patients with either first-episode or chronic schizophrenia with controls using high-resolution volumetric magnetic resonance imaging (MRI) scans. METHOD: Thirteen patients with first-episode schizophrenia, 27 with chronic schizophrenia and 31 controls had 1.5 mm coronal slices taken through the whole brain using a spoiled-grass MRI acquisition protocol. RESULTS: The parahippocampal gyrus was reduced significantly on the left side in patients with chronic schizophrenia compared with controls for both male and female patients, whereas the hippocampus was reduced significantly on both sides only in female patients. There were no significant reductions in any structure between patients with first-episode schizophrenia and controls. CONCLUSIONS: Volumetric reduction seen in patients with chronic schizophrenia may be due to an active degenerative process occurring after the onset of illness.
机译：背景：已有许多研究报道精神分裂症患者海马区或其他边缘结构的体积减少，但文献并不一致。目的：使用高分辨率体积磁共振成像（MRI）扫描比较患有首发或慢性精神分裂症的患者与对照患者。方法：13例首发精神分裂症患者，27例慢性精神分裂症患者和31例对照患者采用全草MRI采集方案从全脑切取1.5 mm冠状切片。结果：与男性和女性相比，慢性精神分裂症患者左侧海马旁回明显减少，而仅女性患者两侧海马明显减少。首发精神分裂症患者与对照组之间的任何结构均无明显减少。结论：慢性精神分裂症患者的体积减少可能是由于疾病发作后发生的活跃的退行性过程。

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