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首页> 外文期刊>The British journal of psychiatry : >Schizophrenia and suicide: systematic review of risk factors.
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Schizophrenia and suicide: systematic review of risk factors.

机译：精神分裂症和自杀：危险因素的系统评价。

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摘要

BACKGROUND: Suicide risk is greatly increased in schizophrenia. Detection of those at risk is clinically important. AIMS: To identify risk factors for suicide in schizophrenia. METHOD: The international literature on case-control and cohort studies of patients with schizophrenia or related conditions in which suicide was reported as an outcome was systematically reviewed. Studies were identified through searching electronic databases and reference lists, and by consulting experts. RESULTS: Twenty-nine eligible studies were identified. Factors with robust evidence of increased risk of suicide were previous depressive disorders (OR=3.03, 95% CI 2.06-4.46), previous suicide attempts (OR=4.09, 95% CI 2.79-6.01), drug misuse (OR=3.21, 95% CI 1.99-5.17), agitation or motor restlessness (OR=2.61, 95% CI 1.54-4.41), fear of mental disintegration (OR=12.1, 95% CI 1.89-81.3), poor adherence to treatment (OR=3.75, 95% CI 2.20-6.37) and recent loss (OR=4.03, 95% CI 1.37-11.8). Reduced risk was associated with hallucinations (OR=0.50, 95% CI 0.35-0.71). CONCLUSIONS: Prevention of suicide in schizophrenia is likely to result from treatment of affective symptoms, improving adherence to treatment, and maintaining special vigilance in patients with risk factors, especially after losses.
机译：背景：精神分裂症的自杀风险大大增加。对有风险的人进行检测在临床上很重要。目的：确定精神分裂症中自杀的危险因素。方法：系统地回顾了有关文献报道自杀为精神分裂症或相关疾病的病例对照研究和队列研究的国际文献。通过搜索电子数据库和参考列表以及咨询专家来鉴定研究。结果：确定了29项合格研究。有充分证据表明自杀风险增加的因素是先前的抑郁症（OR = 3.03，95％CI 2.06-4.46），先前的自杀未遂（OR = 4.09，95％CI 2.79-6.01），滥用药物（OR = 3.21，95 ％CI 1.99-5.17），躁动不安或运动不安定（OR = 2.61，95％CI 1.54-4.41），害怕精神崩溃（OR = 12.1，95％CI 1.89-81.3），依从性差（OR = 3.75， 95％CI 2.20-6.37）和近期亏损（OR = 4.03，95％CI 1.37-11.8）。降低的风险与幻觉有关（OR = 0.50，95％CI 0.35-0.71）。结论：预防精神分裂症的自杀很可能是由情感症状的治疗，改善对治疗的依从性以及对有危险因素的患者保持特别的警惕，尤其是在失去精神因素后。

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