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首页> 外文期刊>The British journal of psychiatry : >Duloxetine in the prevention of relapse of major depressive disorder: double-blind placebo-controlled study.
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Duloxetine in the prevention of relapse of major depressive disorder: double-blind placebo-controlled study.

机译：度洛西汀预防重度抑郁症复发：双盲安慰剂对照研究。

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BACKGROUND: Relapse rates may be as high as 50% in people with major depressive disorder (MDD) previously treated to remission. AIMS: Duloxetine, an inhibitor of serotonin and noradrenaline reuptake that is licensed in Europe, the USA and elsewhere for the treatment of depressive episodes, was evaluated with regard to its efficacy, safety and tolerability in the prevention of relapse of MDD. METHOD: Adult out-patients with MDD received duloxetine (60 mg daily) for 12 weeks (n=533). Patients who responded to the drug were then randomised to duloxetine(60 mg daily)(n=136) or or placebo placebo (n=142) for 26 weeks. The primary measure of efficacy was time to relapse. RESULTS: Patients who received duloxetine (60 mg daily) experienced significantly longer times to relapse of MDD, and better efficacy, global well-being, and quality-of-life outcomes compared with patients who received placebo. It should be noted that adverse events which occur in discontinuation may mimic some signs of depressive relapse, and were not specifically elicited in this study. CONCLUSIONS: Duloxetine (60 mg daily) is effective in the prevention of relapse of MDD during continuation treatment.
机译：背景：先前患有缓解症的重度抑郁症（MDD）患者的复发率可能高达50％。目的：对度洛西汀（5-羟色胺和去甲肾上腺素再摄取的抑制剂，已在欧洲，美国和其他地方许可用于治疗抑郁发作）进行了评估，以评估其在预防MDD复发方面的功效，安全性和耐受性。方法：MDD成人门诊患者接受度洛西汀（每日60 mg）治疗12周（n = 533）。然后将对药物有反应的患者随机分配至度洛西汀（每日60 mg）（n = 136）或安慰剂安慰剂（n = 142）26周。疗效的主要指标是复发时间。结果：与接受安慰剂的患者相比，接受度洛西汀（每天60 mg）的患者经历MDD复发的时间明显更长，并且具有更好的疗效，整体健康和生活质量。应该注意的是，在停药中发生的不良事件可能模拟了抑郁症复发的某些迹象，并且在本研究中并未明确引起。结论：度洛西汀（每日60 mg）可有效预防持续治疗期间MDD的复发。

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