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首页> 外文期刊>The British journal of psychiatry : >White matter changes and late-life depressive symptoms: longitudinal study.
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White matter changes and late-life depressive symptoms: longitudinal study.

机译：白质变化和晚期抑郁症状：纵向研究。

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BACKGROUND: Evidence from cross-sectional studies suggests a link between cerebral age-related white matter changes and depressive symptoms in older people, although the temporal association remains unclear. AIMS: To investigate age-related white matter changes on magnetic resonance imaging (MRI) as an independent predictor of depressive symptoms at 1 year after controlling for known confounders. METHOD: In a pan-European multicentre study of 639 older adults without significant disability, MRI white matter changes and demographic and clinical variables, including cognitive scores, quality of life, disability and depressive symptoms, were assessed at baseline. Clinical assessments were repeated at 1 year. RESULTS: Using logistic regression analysis, severity of white matter changes was shown to independently and significantly predict depressive symptoms at 1 year after controlling for baseline depressive symptoms, quality of life and worsening disability (P<0.01). CONCLUSIONS: White matter changes pre-date and are associated with the development of depressive symptoms. This has implications for treatment and prevention of depression in later life.
机译：背景：横断面研究的证据表明，与大脑年龄相关的白质变化与老年人的抑郁症状之间存在联系，尽管暂时的关联仍不清楚。目的：在控制已知混杂因素后1年，通过磁共振成像（MRI）研究与年龄相关的白质变化，作为抑郁症状的独立预测因子。方法：在一项泛欧洲多中心研究中，对639名无明显残疾的老年人进行了研究，在基线时评估了MRI白质变化以及人口统计和临床变量，包括认知评分，生活质量，残疾和抑郁症状。在1年时重复进行临床评估。结果：使用逻辑回归分析显示，在控制了基线抑郁症状，生活质量和残疾加剧之后，白质变化的严重程度独立且可显着预测抑郁症状在1年时的发生率（P <0.01）。结论：白质发生在变化之前，并且与抑郁症状的发展有关。这对以后生活中抑郁症的治疗和预防具有影响。

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