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首页> 外文期刊>The British journal of psychiatry : >Late-life depression and mortality: influence of gender and antidepressant use.
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Late-life depression and mortality: influence of gender and antidepressant use.

机译：晚期抑郁症和死亡率：性别和抗抑郁药使用的影响。

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BACKGROUND: Depression may increase the risk of mortality among certain subgroups of older people, but the part played by antidepressants in this association has not been thoroughly explored. AIMS: To identify the characteristics of older populations who are most at risk of dying, as a function of depressive symptoms, gender and antidepressant use. METHOD: Adjusted Cox proportional hazards models were used to determine the association between depression and/or antidepressant use and 4-year survival of 7,363 community-dwelling elderly people. Major depressive disorder was evaluated using a standardised psychiatric examination based on DSM-IV criteria and depressive symptoms were assessed using the Center for Epidemiological Studies-Depression scale. RESULTS: Depressed men using antidepressants had the greatest risk of dying, with increasing depression severity corresponding to a higher hazard risk. Among women, only severe depression in the absence of treatment was significantly associated with mortality. CONCLUSIONS: The association between depression and mortality is gender-dependent and varies according to symptom load and antidepressant use.
机译：背景：抑郁症可能会增加某些老年人亚组中的死亡风险，但抗抑郁药在这一关联中所起的作用尚未得到充分探讨。目的：根据抑郁症状，性别和抗抑郁药的使用，确定最容易死亡的老年人群的特征。方法：使用修正的Cox比例风险模型确定抑郁和/或抗抑郁药的使用与7363名社区居民的4年生存率之间的关系。使用基于DSM-IV标准的标准精神病学检查评估了重度抑郁症，并使用流行病学研究中心-抑郁量表对抑郁症状进行了评估。结果：使用抗抑郁药的抑郁症患者死亡风险最高，而抑郁症严重程度增加则意味着较高的危险风险。在妇女中，只有在没有治疗的情况下严重的抑郁与死亡率显着相关。结论：抑郁症和死亡率之间的关联是性别依赖性的，并随症状负荷和抗抑郁药的使用而变化。

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