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首页> 外文期刊>The British journal of psychiatry : >Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis.
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Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis.

机译：双相情感障碍和精神分裂症的磁共振成像研究：荟萃分析。

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BACKGROUND: Several magnetic resonance imaging (MRI) studies have identified structural abnormalities in association with bipolar disorder. The literature is, however, heterogeneous and there is remaining uncertainty about which brain areas are pivotal to the pathogenesis of the condition. AIMS: To identify, appraise and summarise volumetric MRI studies of brain regions comparing bipolar disorder with an unrelated control group and individuals with schizophrenia. METHOD: A systematic review and random-effects meta-analysis was carried out to identify key areas of structural abnormality in bipolar disorder and whether the pattern of affected areas separated bipolar disorder from schizophrenia. Significant heterogeneity was explored using meta-regression. RESULTS: Participants with bipolar disorder are characterised by whole brain and prefrontal lobe volume reductions, and also by increases in the volume of the globus pallidus and lateral ventricles. In comparison with schizophrenia, bipolar disorder is associated with smaller lateral ventricular volume and enlarged amygdala volume. Heterogeneity was widespread and could be partly explained by clinical variables and year of publication, but generally not by differences in image acquisition. CONCLUSIONS: There appear to be robust changes in brain volume in bipolar disorder compared with healthy volunteers, although most changes do not seem to be diagnostically specific. Age and duration of illness appear to be key issues in determining the magnitude of observed effect sizes.
机译：背景：一些磁共振成像（MRI）研究已经确定了与双相情感障碍有关的结构异常。但是，文献是异类的，关于哪个大脑区域对这种疾病的发病机理至关重要，仍然存在不确定性。目的：鉴定，评估和总结大脑区域的容积MRI研究，将双相情感障碍与一个无关的对照组和精神分裂症患者进行比较。方法：通过系统回顾和随机效应荟萃分析，确定双相情感障碍结构异常的关键区域，以及受影响区域的模式是否将双相情感障碍与精神分裂症区分开。使用元回归探索了显着的异质性。结果：患有双相情感障碍的患者的特征是全脑和额叶前叶体积减少，以及苍白球和侧脑室体积增加。与精神分裂症相比，双相情感障碍与较小的侧脑室容积和杏仁核增大有关。异质性很普遍，可以部分地由临床变量和出版年份来解释，但通常不能由图像获取方面的差异来解释。结论：与健康志愿者相比，双相情感障碍的脑容量似乎有明显的变化，尽管大多数变化似乎都不具有诊断特异性。疾病的年龄和持续时间似乎是确定观察到的效应大小的关键问题。

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