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首页> 外文期刊>The British journal of psychiatry : >Polymorphisms in 6D/VF(Val66Met) and 5-HTJLPR, morning cortisol and subsequent depression in at-risk adolescents
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Polymorphisms in 6D/VF(Val66Met) and 5-HTJLPR, morning cortisol and subsequent depression in at-risk adolescents

机译：高危青少年6D / VF（Val66Met）和5-HTJLPR，早晨皮质醇和随后的抑郁症的多态性

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Background There is increasing evidence for genetic effects on the hypothalamic-pituitary axis system. More than one gene is likely to moderate corticoid-mediated activity. Aims To investigate whether the brain-derived neurotrophic factor (BDNF) polymorphism (rs6265, Val66Met) is associated with morning waking salivan/ cortisol and moderates the corticoid-mediated risk for subsequent depressive episode onset independently of the known effects of 5-HTTLPR (the serotonin transporter gene promoter). Method High-risk adolescents (n=40D were genotyped for Val66Met BDNF and 5-HTTLPR. Salivary samples were obtained on four consecutive school days within 1 h of waking. There were 365 (91%) remaining participants reassessed at 12 months for episodes of psychiatric disorder in the follow-up period. Of these, 357 (89%) had complete data for multivariate modelling. Results There were 41 (11.2%) individuals who reported a new episode of clinical depression over the follow-up period. Increased risk for subsequent depression was found in carriers of the Val66Val genotype in BDNF with higher morning waking cortisol. This remained present when the known interaction between carriers of a short allele of 5-HTTLPR with higher morning salivary cortisol was taken into account. Conclusions Both BDNF and 5-HTTLPR genes show evidence of modifying the risk of a subsequent new depressive episode associated with elevated morning salivary cortisol. In adolescents morning salivary cortisol levels may constitute a biomarker for some forms of unipolar depression.
机译：背景技术有越来越多的证据表明遗传会对下丘脑-垂体轴系统产生影响。一个以上的基因可能会介导皮质激素介导的活性。目的探讨脑源性神经营养因子（BDNF）多态性（rs6265，Val66Met）是否与清醒的salivan /皮质醇有关，并缓解皮质激素介导的随后抑郁发作的风险，而与5-HTTLPR（血清素转运蛋白基因启动子）。方法对高危青少年（n = 40D）进行Val66Met BDNF和5-HTTLPR基因分型，在清醒后1小时内连续4个上课日获取唾液样本，还有365名（91％）剩余参与者在12个月时因发作而重新评估随访期间的精神病患者，其中357（89％）人具有完整的多变量建模数据;结果有41（11.2％）个人报告了随访期间新的临床抑郁发作。 BDNF的Val66Val基因型携带者在早上醒来的皮质醇较高时发现了随后的抑郁症;考虑到5-HTTLPR短等位基因的携带者与早上唾液皮质醇的相互作用时，这种情况仍然存在。 5-HTTLPR基因显示出可以改变与早晨唾液皮质醇升高相关的新的抑郁发作风险的证据，在青少年中，早晨唾液皮质醇水平可能会降低对某些形式的单极抑郁症的生物标志物进行测试。

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