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首页> 外文期刊>The British journal of psychiatry : >Relationship between disabling fatigue and depression in children: genetic study.
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Relationship between disabling fatigue and depression in children: genetic study.

机译：儿童残疾疲劳与抑郁之间的关系：遗传研究。

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BACKGROUND: Medically unexplained disabling fatigue in young people is familial and frequently associated with depressed mood. AIMS: To examine the degree of sharing of genetic and environmental influences on the symptoms of depression and fatigue in this age group. METHOD: The parents of twins aged 8-17 years, derived from a population-based register, completed a questionnaire regarding lifetime-ever disabling fatigue in both twins. Twins aged 11 years or over completed the Mood and Feelings Questionnaire. The genetic and environmental influences on fatigue and the relationship with depression were examined using bivariate genetic analysis. RESULTS: Parent-rated data were obtained for 1468 twin pairs (65%) and self-rated data from 930 older twin pairs (58%). Bivariate analysis of fatigue and depression suggested that genetic and environmental influences on disabling fatigue were mainly specific to fatigue. CONCLUSIONS: Unexplained disabling fatigue in childhood is substantially familial and has mainlyan independent aetiology from depression.
机译：背景：医学上无法解释的年轻人致残疲劳是家族性疾病，常常与情绪低落有关。目的：研究遗传和环境影响在这个年龄段的抑郁和疲劳症状中的共享程度。方法：基于人口登记册的8-17岁双胞胎父母填写了一份有关双胞胎终生致残疲劳的调查表。 11岁或11岁以上的双胞胎完成了情绪和情感问卷。使用双变量遗传分析检查了遗传和环境因素对疲劳的影响以及与抑郁的关系。结果：获得了1468对双胞胎的父母评价数据（65％），以及来自930对老年双胞胎的自我评价数据（58％）。对疲劳和抑郁的双变量分析表明，遗传和环境对残疾疲劳的影响主要是疲劳所特有的。结论：儿童无法解释的致残性疲劳基本上是家族性的，主要是与抑郁症相关的独立病因。

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