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首页> 外文期刊>The British journal of psychiatry : >Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies.
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Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies.

机译：首发精神分裂症的脑容量：磁共振成像研究的系统综述和荟萃分析。

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BACKGROUND: Studies of people with schizophrenia assessed using magnetic resonance imaging (MRI) usually include patients with first-episode and chronic disease, yet brain abnormalities may be limited to those with chronic schizophrenia. AIMS: To determine whether patients with a first episode of schizophrenia have characteristic brain abnormalities. METHOD: Systematic review and meta-analysis of 66 papers comparing brain volume in patients with a first psychotic episode with volume in healthy controls. RESULTS: A total of 52 cross-sectional studies included 1424 patients with a first psychotic episode; 16 longitudinal studies included 465 such patients. Meta-analysis suggests that whole brain and hippocampal volume are reduced (both P<0.0001) and that ventricular volume is increased (P<0.0001) in these patients relative to healthy controls. CONCLUSIONS: Average volumetric changes are close to the limit of detection by MRI methods. It remains to be determined whether schizophrenia is a neurodegenerative process that begins at about the time of symptom onset, or whether it is better characterised as a neurodevelopmental process that produces abnormal brain volumes at an early age.
机译：背景：使用磁共振成像（MRI）评估的精神分裂症患者的研究通常包括首发和慢性疾病的患者，但脑部异常可能仅限于患有慢性精神分裂症的患者。目的：确定患有首发精神分裂症的患者是否具有特征性的大脑异常。方法：对66篇论文的系统评价和荟萃分析，比较了第一次精神病发作患者的脑容量与健康对照者的脑容量。结果：总共52项横断面研究包括1424例首次出现精神病发作的患者。 16项纵向研究包括465名此类患者。荟萃分析表明，相对于健康对照组，这些患者的全脑和海马体积减少（均P <0.0001），并且心室体积增加（P <0.0001）。结论：平均体积变化接近MRI方法的检测极限。精神分裂症是大约在症状发作时开始的神经退行性过程，还是更好地表征为在早期就产生异常脑容量的神经发育过程，尚待确定。

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