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首页> 外文期刊>The British journal of psychiatry : >Influence of 5-HT2C receptor and leptin gene polymorphisms, smoking and drug treatment on metabolic disturbances in patients with schizophrenia.
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Influence of 5-HT2C receptor and leptin gene polymorphisms, smoking and drug treatment on metabolic disturbances in patients with schizophrenia.

机译：5-HT2C受体和瘦素基因多态性，吸烟和药物治疗对精神分裂症患者代谢紊乱的影响。

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摘要

BACKGROUND: Obesity and metabolic syndrome are significant problems for patients taking antipsychotic drugs. Evidence is emerging of genetic risk factors. AIMS: To investigate the influence of two candidate genes, smoking and drug treatment on obesity and metabolic syndrome in patients with schizophrenia. METHOD: Patients (n=134) were assessed for measures of obesity, other factors contributing to metabolic syndrome, and two genetic polymorphisms (5-HT(2C) receptor -759C/T and leptin -2548A/G). RESULTS: Neither genotype nor smoking was significantly associated with measures of obesity. However, both leptin genotype and smoking were significantly associated with metabolic syndrome. Significant interaction occurred between the genetic polymorphisms for effects on obesity, whereby a genotype combination increased risk. Drug treatment showed significant effects on measures of obesity and triglyceride concentrations; risperidone was associated with lower values than olanzapine or clozapine. CONCLUSIONS: Thefindings suggest interacting genetic risk factors and smoking influence development of metabolic syndrome in patients on antipsychotic drugs.
机译：背景：肥胖和代谢综合征是服用抗精神病药的患者的重大问题。遗传危险因素的证据正在出现。目的：探讨吸烟和药物治疗这两种候选基因对精神分裂症患者肥胖和代谢综合征的影响。方法：对患者（n = 134）进行了肥胖，其他导致代谢综合征的因素和两种遗传多态性（5-HT（2C）受体-759C / T和瘦素-2548A / G）的评估。结果：基因型和吸烟均与肥胖程度无显着相关性。然而，瘦素基因型和吸烟都与代谢综合征显着相关。遗传多态性之间发生了显着的相互作用，从而影响了肥胖，因此基因型组合增加了患病风险。药物治疗对肥胖和甘油三酸酯浓度的测量显示出显着影响;利培酮的价值低于奥氮平或氯氮平。结论：研究结果表明相互作用的遗传危险因素和吸烟影响抗精神病药物患者代谢综合征的发展。

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