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首页> 外文期刊>The British journal of psychiatry : >Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis.
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Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis.

机译:在精神病的前驱状态下,脑脊液中Anandamide升高。

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摘要

Anandamide is a bioactive lipid binding to cannabinoid receptors. A homeostatic role for anandamide has been suggested in schizophrenia. We investigated its role in initial prodromal states of psychosis. We measured the levels of anandamide and its structural analog oleoylethanolamide in cerebrospinal fluid and serum of patients in the initial prodromal state (n=27) alongside healthy volunteers (n=81) using high-performance liquid chromatograph/mass spectrometry. Cerebrospinal anandamide levels in patients were significantly elevated. Patients with lower levels showed a higher risk for transiting to psychosis earlier. This anandamidergic up-regulation in the initial prodromal course may suggest a protective role of the endocannabinoid system in early schizophrenia.
机译:Anandamide是一种结合大麻素受体的生物活性脂质。在精神分裂症中已提出了对anandamide具有稳态作用。我们调查了其在精神病的前驱状态中的作用。我们使用高效液相色谱/质谱法测量了初始前驱状态(n = 27)和健康志愿者(n = 81)的患者的脑脊液和血清中的anandamide及其结构类似物油酰基乙醇酰胺的水平。患者的脑脊髓中的安南酰胺水平显着升高。较低水平的患者显示出较早过渡为精神病的较高风险。前驱过程中这种anandamidergic上调可能表明内源性大麻素系统在早期精神分裂症中具有保护作用。

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