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首页> 外文期刊>The British journal of psychiatry : >Changes in regional cerebral blood flow during acute electroconvulsive therapy in patients with depression: positron emission tomographic study.
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Changes in regional cerebral blood flow during acute electroconvulsive therapy in patients with depression: positron emission tomographic study.

机译：抑郁症患者急性电惊厥治疗期间局部脑血流的变化：正电子发射断层扫描研究。

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BACKGROUND: Although electroconvulsive therapy (ECT) is widely used to treat psychiatric disorders such as depression, its precise neural mechanisms remain unknown. AIMS: To investigate the time course of changes in cerebral blood flow during acute ECT. METHOD: Cerebral blood flow was quantified serially prior to, during and after acute ECT in six patients with depression under anaesthesia using [(15)O]H(2)O positron emission tomography (PET). RESULTS: Cerebral blood flow during ECT increased particularly in the basal ganglia, brain-stem, diencephalon, amygdala, vermis and the frontal, temporal and parietal cortices compared with that before ECT. The flow increased in the thalamus and decreased in the anterior cingulate and medial frontal cortex soon after ECT compared with that before ECT. CONCLUSIONS: These results suggest a relationship between the centrencephalic system and seizure generalisation. Further, they suggest that some neural mechanisms of action of ECT are mediated via brain regions including the anterior cingulate and medial frontal cortex and thalamus.
机译：背景：尽管电惊厥疗法（ECT）被广泛用于治疗精神疾病，例如抑郁症，但其精确的神经机制仍未知。目的：探讨急性ECT期间脑血流变化的时程。方法：采用[（15）O] H（2）O正电子发射断层显像（PET），对6例麻醉下抑郁症患者在急性ECT之前，期间和之后的脑血流进行连续定量。结果：与ECT之前相比，ECT期间的脑血流量特别是在基底神经节，脑干，间脑，杏仁核，ver以及额叶，颞叶和顶叶皮层增加。与ECT前相比，ECT后丘脑的血流增加，前扣带和额叶内侧皮层血流减少。结论：这些结果表明中枢神经系统和癫痫发作的普遍性之间的关系。此外，他们表明，ECT的一些神经机制是通过大脑区域介导的，包括前扣带回和内侧额叶皮层和丘脑。

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