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首页> 外文期刊>The British journal of psychiatry : >Effect of age at onset of schizophrenia on white matter abnormalities.
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Effect of age at onset of schizophrenia on white matter abnormalities.

机译：精神分裂症发病年龄对白质异常的影响。

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BACKGROUND: The pattern of brain morphological changes at the early stages of schizophrenia may depend on the age at onset of illness; in children and adolescents with schizophrenia, grey matter deficits are seen in the parietal lobe whereas in individuals with adult onset these are more widespread. AIMS: To examine whether white matter is similarly affected. METHOD: Diffusion tensor imaging was used to compare fractional anisotropy measures in individuals with adolescent-onset (n = 17) and adult-onset schizophrenia (n = 17) with those in age- and gender-matched controls. RESULTS: Compared with their respective controls, individuals with adolescent-onset schizophrenia showed fractional anisotropy decrease in parietal regions; individuals with adult onset showed additional fractional anisotropy reductions in frontal, temporal and cerebellar regions. A differential effect of age at onset (adolescent v. adult) was noted bilaterally in medial prefrontal white matter. CONCLUSIONS: White matter abnormalities in frontal regions in schizophrenia may depend on developmental stage at the time of illness onset.
机译：背景：精神分裂症早期的大脑形态变化模式可能取决于发病年龄。在患有精神分裂症的儿童和青少年中，在顶叶中可见灰质缺乏，而在成年发病的个体中灰质缺乏更为普遍。目的：检查白质是否同样受到影响。方法：采用弥散张量成像技术，比较青少年期（n = 17）和成人期精神分裂症（n = 17）与年龄和性别相匹配的对照人群的分数各向异性测量。结果：与对照相比，青少年期精神分裂症患者的顶叶区域各向异性有所降低。成年发病的个体在额叶，颞叶和小脑区域表现出额外的分数各向异性降低。在内侧前额叶白质中，双侧观察到发病年龄（青少年对成人）的不同影响。结论：精神分裂症额叶白质异常可能取决于疾病发作时的发育阶段。

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