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首页> 外文期刊>The British journal of psychiatry : >Prediction of transition from common adolescent bipolar experiences to bipolar disorder: 10-year study.
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Prediction of transition from common adolescent bipolar experiences to bipolar disorder: 10-year study.

机译：从青春期常见的双相情感障碍过渡到双相情感障碍的预测：十年研究。

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BACKGROUND: Although (hypo)manic symptoms are common in adolescence, transition to adult bipolar disorder is infrequent. AIMS: To examine whether the risk of transition to bipolar disorder is conditional on the extent of persistence of subthreshold affective phenotypes. METHOD: In a 10-year prospective community cohort study of 3021 adolescents and young adults, the association between persistence of affective symptoms over 3 years and the 10-year clinical outcomes of incident DSM-IV (hypo)manic episodes and incident use of mental healthcare was assessed. RESULTS: Transition to clinical outcome was associated with persistence of symptoms in a dose-dependent manner. Around 30-40% of clinical outcomes could be traced to prior persistence of affective symptoms. CONCLUSIONS: In a substantial proportion of individuals, onset of clinical bipolar disorder may be seen as the poor outcome of a developmentally common and usually transitory non-clinical bipolar phenotype.
机译：背景：尽管（低）躁狂症状在青春期很常见，但很少发生向成人双相情感障碍的转变。目的：检查是否有阈值以下的情感表型持续存在，是否可以转变为躁郁症的风险。方法：在一项针对3021名青少年和青少年的为期10年的前瞻性社区队列研究中，超过3年的情感症状持续存在与DSM-IV（低）躁狂事件的10年临床结局和精神事件的使用之间的关联评估医疗保健。结果：过渡至临床结局与症状的持续存在呈剂量依赖性。大约30-40％的临床结果可以追溯到情感症状的持续存在。结论：在很大比例的个体中，临床上双相情感障碍的发作可能被视为发育常见且通常是短暂的非临床双相表型的不良结果。

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