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首页> 外文期刊>The British journal of psychiatry : >Visual cortex in dementia with Lewy bodies: Magnetic resonance imaging study
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Visual cortex in dementia with Lewy bodies: Magnetic resonance imaging study

机译：路易氏体痴呆患者的视觉皮层：磁共振成像研究

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摘要

Background: Visual hallucinations and visuoperceptual deficits are common in dementia with Lewy bodies, suggesting that cortical visual function may be abnormal. Aims: To investigate: (1) cortical visual function using functional magnetic resonance imaging (fMRI); and (2) the nature and severity of perfusion deficits in visual areas using arterial spin labelling (ASL)-MRI. Method: In total, 17 participants with dementia with Lewy bodies (DLB group) and 19 similarly aged controls were presented with simple visual stimuli (checkerboard, moving dots, and objects) during fMRI and subsequently underwent ASL-MRI (DLB group n = 15, control group n = 19). Results: Functional activations were evident in visual areas in both the DLB and control groups in response to checkerboard and objects stimuli but reduced visual area V5/MT (middle temporal) activation occurred in the DLB group in response to motion stimuli. Posterior cortical perfusion deficits occurred in the DLB group, particularly in higher visual areas. Conclusions: Higher visual areas, particularly occipito-parietal, appear abnormal in dementia with Lewy bodies, while there is a preservation of function in lower visual areas (V1 and V2/3).
机译：背景：视觉幻觉和视觉感受器缺陷在路易体痴呆症中很常见，提示皮质视觉功能可能异常。目的：研究：（1）使用功能磁共振成像（fMRI）的皮层视觉功能; （2）使用动脉自旋标记（ASL）-MRI进行视觉区域灌注不足的性质和严重程度。方法：总共有17名路易体痴呆参与者（DLB组）和19名年龄相似的对照在功能性磁共振成像过程中表现出简单的视觉刺激（棋盘，运动点和物体），随后接受了ASL-MRI（DLB组n = 15） ，对照组n = 19）。结果：DLB组和对照组中的视觉区域均响应棋盘和物体刺激而明显激活了功能性激活，但DLB组中的视觉区域V5 / MT（中颞叶）激活的降低是由于运动刺激而引起的。 DLB组发生后皮质灌注不足，特别是在较高视力区域。结论：高视力区，特别是枕顶叶，在路易体痴呆症中出现异常，而低视力区（V1和V2 / 3）则保留了功能。

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