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首页> 外文期刊>The British journal of psychiatry : >Late-life depression and risk of vascular dementia and Alzheimer's disease: Systematic review and meta-analysis of community-based cohort studies
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Late-life depression and risk of vascular dementia and Alzheimer's disease: Systematic review and meta-analysis of community-based cohort studies

机译：晚期抑郁症和血管性痴呆和阿尔茨海默氏病的风险：基于社区的队列研究的系统评价和荟萃分析

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Background: Late-life depression may increase the risk of incident dementia, in particular of Alzheimer's disease and vascular dementia. Aims: To conduct a systematic review and meta-analysis to evaluate the risk of incident all-cause dementia, Alzheimer's disease and vascular dementia in individuals with late-life depression in population-based prospective studies. Method: A total of 23 studies were included in the meta-analysis. We used the generic inverse variance method with a random-effects model to calculate the pooled risk of dementia, Alzheimer's disease and vascular dementia in older adults with late-life depression. Results: Late-life depression was associated with a significant risk of all-cause dementia (1.85, 95% CI 1.67-2.04, P < 0.001), Alzheimer's disease (1.65, 95% CI 1.42-1.92, P < 0.001) and vascular dementia (2.52, 95% CI 1.77-3.59, P < 0.001). Subgroup analysis, based on five studies, showed that the risk of vascular dementia was significantly higher than for Alzheimer's disease (P = 0.03). Conclusions: Late-life depression is associated with an increased risk for all-cause dementia, vascular dementia and Alzheimer's disease. The present results suggest that it will be valuable to design clinical trials to investigate the effect of late-life depression prevention on risk of dementia, in particular vascular dementia and Alzheimer's disease.
机译：背景：晚年抑郁症可能增加发生痴呆症的风险，尤其是阿尔茨海默氏病和血管性痴呆的风险。目的：在基于人群的前瞻性研究中，进行系统评价和荟萃分析，以评估晚期抑郁症患者发生全因痴呆，阿尔茨海默氏病和血管性痴呆的风险。方法：荟萃分析共纳入23项研究。我们使用具有随机效应模型的通用逆方差方法来计算患有晚期抑郁症的老年人的痴呆症，阿尔茨海默氏病和血管性痴呆的合并风险。结果：晚期抑郁症与全因痴呆（1.85，95％CI 1.67-2.04，P <0.001），阿尔茨海默氏病（1.65，95％CI 1.42-1.92，P <0.001）和血管的重大风险相关痴呆（2.52，95％CI 1.77-3.59，P <0.001）。基于五项研究的亚组分析显示，血管性痴呆的风险显着高于阿尔茨海默氏病（P = 0.03）。结论：晚期抑郁症与全因痴呆，血管性痴呆和阿尔茨海默氏病风险增加有关。目前的结果表明，设计临床试验来研究预防晚期抑郁症对痴呆症（尤其是血管性痴呆和阿尔茨海默氏病）风险的影响将是有价值的。

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