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首页> 外文期刊>The British journal of psychiatry : >Childhood maltreatment and methylation of the glucocorticoid receptor gene NR3C1 in bipolar disorder
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Childhood maltreatment and methylation of the glucocorticoid receptor gene NR3C1 in bipolar disorder

机译：双相情感障碍儿童时期糖皮质激素受体基因NR3C1的虐待和甲基化

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Background Early-life adversities represent risk factors for the development of bipolar affective disorder and are associated with higher severity of the disorder. This may be the consequence of a sustained alteration of the hypothalamic-pituitary-adrenal (HPA) axis resulting from epigenetic modifications of the gene coding for the glucocorticoid receptor (NR3C1). Aims To investigate whether severity of childhood maltreatment isassociated with increased methylation of the exon 1F NR3C1 promoter in bipolar disorder. Method A sample of people with bipolar disorder (n = 99) were assessed for childhood traumatic experiences. The percentage of NR3C1 methylation was measured for each participant.Results The higher the number of trauma events, the higher was the percentage of NR3C1 methylation (β = 0.52, 95% CI 0.46-0.59, P"0.0001). The severity of each type of maltreatment (sexual, physical and emotional) was also associated with NR3C1 methylation status. ConclusionsEarly-life adversities have a sustained effect on the HPA axis through epigenetic processes and this effect may be measured in peripheral blood. This enduring biological impact of early trauma may alter the development of the brain and lead to adult psychopathological disorder. Declaration of interest None.
机译：背景技术早期生活中的逆境是双相情感障碍发展的危险因素，并且与该病的严重程度有关。这可能是由于编码糖皮质激素受体（NR3C1）的基因的表观遗传修饰导致下丘脑-垂体-肾上腺（HPA）轴持续变化的结果。目的探讨双相情感障碍中儿童虐待的严重程度是否与外显子1F NR3C1启动子的甲基化增加有关。方法对双相情感障碍患者（n = 99）的样本进行儿童期创伤经历评估。结果各创伤事件的发生率越高，NR3C1甲基化的百分比越高（β= 0.52，95％CI 0.46-0.59，P“ 0.0001）。每种类型的严重程度结论（性，身体和情感上的虐待）也与NR3C1甲基化状态有关。改变大脑的发育并导致成人心理病理障碍。

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