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首页> 外文期刊>The British journal of psychiatry : >Distinguishing characteristics of subjects with good and poor early outcome in the Edinburgh High-Risk Study.
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Distinguishing characteristics of subjects with good and poor early outcome in the Edinburgh High-Risk Study.

机译：在爱丁堡高风险研究中区分早期结果好和差的受试者的特征。

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Background 'High-risk' studies of schizophrenia have the potential to clarify the pathogenesis of schizophrenia. Here, results of extreme outcome groups in the Edinburgh High-Risk Study are presented. Aims To compare groups of good and poor outcome from the Edinburgh High-Risk Study and clarify the nature of the change from the state of vulnerability to that of developing psychosis. Method The recruitment procedure is described. Good and poor outcome are defined. These groups are compared in terms of genetic liability and of baseline and change in neuropsychology and neuroanatomy. Results Demographic characteristics and genetic liability do not differ between the groups. The good outcome group perform better at baseline in some neuropsychological tests, but there is little neuroanatomical difference. The poor outcome group show consistently impaired memory function and a tendency to reduction in temporal lobe size. Conclusions In genetically predisposed subjects, the change from vulnerability to developing psychosis may be marked by a reduced size and impaired function of the temporal lobe.
机译：背景对精神分裂症的“高风险”研究有可能阐明精神分裂症的发病机理。在此，介绍了爱丁堡高风险研究中极端结果组的结果。目的比较爱丁堡高风险研究的好坏结果，并阐明从脆弱状态到发展性精神病的变化的本质。方法描述招聘程序。定义好与坏的结果。根据遗传责任和基线以及神经心理学和神经解剖学的变化比较这些组。结果两组间的人口统计学特征和遗传责任没有差异。在某些神经心理学测试中，良好结局组在基线时表现更好，但神经解剖学差异很小。结果差的组表现出持续的记忆功能受损和颞叶尺寸减小的趋势。结论在遗传易感人群中，从易感性向发展性精神病的转变可能以颞叶尺寸减小和功能受损为特征。

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